Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation - sprookjes - yvandenbroek - TriplyDB

Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation

Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation

http://www.wikidata.org/entity/Q24656036

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Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances How insulin engages its primary binding site on the insulin receptor Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists Structural and Biological Properties of the Drosophila Insulin-like Peptide 5 Show Evolutionary Conservation A rule-based model of insulin signalling pathway A hierarchical whole-body modeling approach elucidates the link between in Vitro insulin signaling and in Vivo glucose homeostasis.Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways Mechanisms of activation of receptor tyrosine kinases: monomers or dimers.Allosteric transition: a comparison of two models Agonism and antagonism at the insulin receptor.Computational modelling of the regulation of Insulin signalling by oxidative stress.Flexibility in the insulin receptor ectodomain enables docking of insulin in crystallographic conformation observed in a hormone-bound microreceptor.Separation of fast from slow anabolism by site-specific PEGylation of insulin-like growth factor I (IGF-I).Mathematical modeling of the insulin signal transduction pathway for prediction of insulin sensitivity from expression data.Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II.A high-level language for rule-based modelling.Insulin Signaling in Insulin Resistance States and Cancer: A Modeling Analysis.Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes.Preferential impact of pregnancy-associated plasma protein-A deficiency on visceral fat in mice on high-fat diet.Insulin-like growth factor-II (IGF-II) and IGF-II analogs with enhanced insulin receptor-a binding affinity promote neural stem cell expansion Rule-based modeling: a computational approach for studying biomolecular site dynamics in cell signaling systems.Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.Radioligand dissociation measurements: potential interference of rebinding and allosteric mechanisms and physiological relevance of the biological model systems.The IGF-1 receptor and regulation of nitric oxide bioavailability and insulin signalling in the endothelium.Theoretical and computational studies of peptides and receptors of the insulin family.Requirements for multi-level systems pharmacology models to reach end-usage: the case of type 2 diabetes.Cross-talks via mTORC2 can explain enhanced activation in response to insulin in diabetic patients.A systems biology analysis connects insulin receptor signaling with glucose transporter translocation in rat adipocytes.A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation.Mass and information feedbacks through receptor endocytosis govern insulin signaling as revealed using a parameter-free modeling framework.A framework for mapping, visualisation and automatic model creation of signal-transduction networks.The impact of mathematical modeling on the understanding of diabetes and related complications.Structural basis of the aberrant receptor binding properties of hagfish and lamprey insulins.Quantitative Analysis of Robustness of Dynamic Response and Signal Transfer in Insulin mediated PI3K/AKT Pathway.Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex.Quasi-Steady-State Analysis based on Structural Modules and Timed Petri Net Predict System's Dynamics: The Life Cycle of the Insulin Receptor.A modelling-experimental approach reveals insulin receptor substrate (IRS)-dependent regulation of adenosine monosphosphate-dependent kinase (AMPK) by insulin.Identification of insulin-sensitizing molecules acting by disrupting the interaction between the Insulin Receptor and Grb14.Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor.A closed-loop multi-level model of glucose homeostasis.

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P2860

Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation

http://www.wikidata.org/entity/Q24656036

description

2009 nî lūn-bûn

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2009 թուականին հրատարակուած գիտական յօդուած

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2009 թվականին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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Harmonic oscillator model of t ...... osteric binding and activation

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Harmonic oscillator model of t ...... osteric binding and activation

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Harmonic oscillator model of t ...... osteric binding and activation

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type

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Harmonic oscillator model of t ...... osteric binding and activation

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Harmonic oscillator model of t ...... osteric binding and activation

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Harmonic oscillator model of t ...... osteric binding and activation

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Harmonic oscillator model of t ...... osteric binding and activation

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Harmonic oscillator model of t ...... osteric binding and activation

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Harmonic oscillator model of t ...... osteric binding and activation

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Molecular Systems Biology

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Harmonic oscillator model of t ...... osteric binding and activation

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Lisbeth Gauguin

http://www.w3.org/2001/XMLSchema#string

Soetkin Versteyhe

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Vladislav V Kiselyov

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P2860

Alanine scanning of a putative receptor binding surface of insulin-like growth factor-I

Structural origins of the functional divergence of human insulin-like growth factor-I and insulin

Insulin and its receptor: structure, function and evolution.

High-affinity insulin binding: insulin interacts with two receptor ligand binding sites.

Structure and function of the type 1 insulin-like growth factor receptor.

Structural biology of insulin and IGF1 receptors: implications for drug design.

Insulin interactions with its receptors: experimental evidence for negative cooperativity.

Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

Kinetic proofreading in T-cell receptor signal transduction.

The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.

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243

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scholarly article

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1108706

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10.1038/MSB.2008.78

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P478

5

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Pierre De Meyts

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2009-01-01T00:00:00Z

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24023421

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19225456

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information system

applied mathematics

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2657531

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