Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons
about
Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.The functional and anatomical dissection of somatosensory subpopulations using mouse geneticsImplication of Genetic Deletion of Wdr13 in Mice: Mild Anxiety, Better Performance in Spatial Memory Task, with Upregulation of Multiple Synaptic Proteins.A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch reliefEndogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7Nav1.7 and other voltage-gated sodium channels as drug targets for pain reliefGlobal Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to painMouse DRG Cell Line with Properties of NociceptorsPeptidomimetic Star Polymers for Targeting Biological Ion ChannelsSubtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.[EXPRESS] Ion channels and neuronal hyperexcitability in chemotherapy-induced peripheral neuropathy; cause and effect?Significant determinants of mouse pain behaviour.A role for Piezo2 in EPAC1-dependent mechanical allodynia.Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.Pain related channels are differentially expressed in neuronal and non-neuronal cells of glabrous skin of fabry knockout male miceA novel SCN9A mutation responsible for primary erythromelalgia and is resistant to the treatment of sodium channel blockersEnhanced behavioral responses to cold stimuli following CGRPα sensory neuron ablation are dependent on TRPM8.Linkage between increased nociception and olfaction via a SCN9A haplotypeThe Fabry disease-associated lipid Lyso-Gb3 enhances voltage-gated calcium currents in sensory neurons and causes pain.Regulation of Nav1.7: A Conserved SCN9A Natural Antisense Transcript Expressed in Dorsal Root Ganglia.Novel sodium channel antagonists in the treatment of neuropathic pain.Post-translational modifications of voltage-gated sodium channels in chronic pain syndromesThe AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development.Development of a Rapid Throughput Assay for Identification of hNav1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, AntillatoxinPeptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold.α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage.MicroRNA-30b regulates expression of the sodium channel Nav1.7 in nerve injury-induced neuropathic pain in the ratSensory Neuron-Specific Deletion of TRPA1 Results in Mechanical Cutaneous Sensory Deficits.Genetic aspects of sodium channelopathy in small fiber neuropathy.Human Mendelian pain disorders: a key to discovery and validation of novel analgesics.Neurological perspectives on voltage-gated sodium channels.Nociception and pain: lessons from optogenetics.Translational pain research: Lessons from genetics and genomics.The role of sodium channels in painful diabetic and idiopathic neuropathy.Pain without nociceptors? Nav1.7-independent pain mechanisms.Alleviation of pain in painful diabetic neuropathy.Challenges to develop novel anti-inflammatory and analgesic drugs.Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.
P2860
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P2860
Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Distinct Nav1.7-dependent pain ...... ensory and sympathetic neurons
@ast
Distinct Nav1.7-dependent pain ...... ensory and sympathetic neurons
@en
Distinct Nav1.7-dependent pain ...... ensory and sympathetic neurons
@nl
type
label
Distinct Nav1.7-dependent pain ...... ensory and sympathetic neurons
@ast
Distinct Nav1.7-dependent pain ...... ensory and sympathetic neurons
@en
Distinct Nav1.7-dependent pain ...... ensory and sympathetic neurons
@nl
prefLabel
Distinct Nav1.7-dependent pain ...... ensory and sympathetic neurons
@ast
Distinct Nav1.7-dependent pain ...... ensory and sympathetic neurons
@en
Distinct Nav1.7-dependent pain ...... ensory and sympathetic neurons
@nl
P2093
P2860
P3181
P356
P1476
Distinct Nav1.7-dependent pain ...... ensory and sympathetic neurons
@en
P2093
Anthony H Dickenson
Gayle Passmore
John N Wood
Michael S Minett
Mohammed A Nassar
P2860
P2888
P3181
P356
10.1038/NCOMMS1795
P407
P577
2012-01-01T00:00:00Z
P5875
P6179
1042974755