Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain. - sprookjes - yvandenbroek - TriplyDB

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

http://www.wikidata.org/entity/Q34385062

about

G-protein-coupled receptor kinases in inflammation and disease Mechanical allodynia Commonalities between pain and memory mechanisms and their meaning for understanding chronic pain Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).Inhibition of Mitochondrial p53 Accumulation by PFT-μ Prevents Cisplatin-Induced Peripheral Neuropathy.[EXPRESS] Epac and Nociceptor Sensitization.Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 "therapeutic window".Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat.Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice.Downregulation of Spinal G Protein-Coupled Kinase 2 Abolished the Antiallodynic Effect of Electroacupuncture Gelsemine alleviates both neuropathic pain and sleep disturbance in partial sciatic nerve ligation mice.The pharmacology of nociceptor priming Sustained Suppression of Hyperalgesia during Latent Sensitization by μ-, δ-, and κ-opioid receptors and α2A Adrenergic Receptors: Role of Constitutive Activity Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.Epac-protein kinase C alpha signaling in purinergic P2X3R-mediated hyperalgesia after inflammation EXPRESS: F-actin links Epac-PKC signaling to purinergic P2X3 receptors sensitization in dorsal root ganglia following inflammation.Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1.Inhibition of Epac1 suppresses mitochondrial fission and reduces neointima formation induced by vascular injury.Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets.A Single Intrathecal or Intraperitoneal Injection of CB2 Receptor Agonist Attenuates Bone Cancer Pain and Induces a Time-Dependent Modification of GRK2.Pro-inflammatory cytokines mediate GPCR dysfunction.Effect of Epac1 on pERK and VEGF Activation in Postoperative Persistent Pain in Rats.SDF1-CXCR4 Signaling Contributes to the Transition from Acute to Chronic Pain State.A cell-based, quantitative and isoform-specific assay for exchange proteins directly activated by cAMP.An Orally Active Epac Inhibitor Reverses Mechanical Allodynia and Loss of Intraepidermal Nerve Fibers \iIn A Mouse Model of Chemotherapy-Induced Peripheral Neuropathy.G Protein-Coupled Receptor Kinases in the Inflammatory Response and Signaling.Identification of FAM173B as a protein methyltransferase promoting chronic pain.Divergent roles of immune cells and their mediators in pain.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Low GRK2 Underlies Hyperalgesic Priming by Glial Cell-Derived Neurotrophic Factor.PKCβII-induced upregulation of PGP9.5 and VEGF in postoperative persistent pain in rats

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P2860

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

http://www.wikidata.org/entity/Q34385062

description

2013 nî lūn-bûn

@nan

2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

@ast

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

@en

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

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type

label

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

@ast

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

@en

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

@nl

prefLabel

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

@ast

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

@en

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

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Journal of Clinical Investigation

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Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain

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Anil K Sood

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Anne Vroon

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Annemieke Kavelaars

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Cobi J Heijnen

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Hanneke L D M Willemen

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Huijing Wang

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Xinna Zhang

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Yoshihiro Ishikawa

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P2860

A family of cAMP-binding proteins that directly activate Rap1

What is this thing called pain?

GRK2: multiple roles beyond G protein-coupled receptor desensitization

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

Prospective study of chronic pain after groin hernia repair

G protein-coupled receptor kinases, beta-arrestin-2 and associated regulatory proteins in the human brain: postmortem changes, effect of age and subcellular distribution

Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis

Cellular and Molecular Mechanisms of Pain

Quantitative assessment of tactile allodynia in the rat paw

Local translation in primary afferent fibers regulates nociception

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5023-5034

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10.1172/JCI66241

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12

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Niels Eijkelkamp

Cindy van Velthoven

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2013-11-15T00:00:00Z

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