Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor
about
Structure-based discovery of opioid analgesics with reduced side effects.A Role for Fragment-Based Drug Design in Developing Novel Lead Compounds for Central Nervous System TargetsLarge-scale production and protein engineering of G protein-coupled receptors for structural studiesNew insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptorsDiscovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal StructureBiophysical Fragment Screening of the β 1 -Adrenergic Receptor: Identification of High Affinity Arylpiperazine Leads Using Structure-Based Drug DesignRoles for Ordered and Bulk Solvent in Ligand Recognition and Docking in Two Related CavitiesFunction-specific virtual screening for GPCR ligands using a combined scoring methodLigand pose and orientational sampling in molecular dockingThe role of experimental and computational structural approaches in 7TM drug discovery.Docking Screens for Novel Ligands Conferring New Biology.Structure-function of the G protein-coupled receptor superfamily.Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid ReceptorStructural Analysis of Chemokine Receptor-Ligand Interactions.Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptorPyPLIF: Python-based Protein-Ligand Interaction Fingerprinting.Fragment-based lead discovery on G-protein-coupled receptors.What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors.Computational studies to predict or explain G protein coupled receptor polypharmacologyCreating and virtually screening databases of fluorescently-labelled compounds for the discovery of target-specific molecular probes.Multiple fragment docking and linking in primary and secondary pockets of dopamine receptors.From G Protein-coupled Receptor Structure Resolution to Rational Drug Design.Structure-Based Virtual Screening for Dopamine D2 Receptor Ligands as Potential Antipsychotics.A Strategy Combining Differential Low-Throughput Screening and Virtual Screening (DLS-VS) Accelerating the Discovery of new Modulators for the Orphan GPR34 Receptor.Identification of Novel Smoothened Ligands Using Structure-Based Docking.Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.Structure-based design of eugenol analogs as potential estrogen receptor antagonistsThe GPCR Network: a large-scale collaboration to determine human GPCR structure and function.Muscarinic receptors as model targets and antitargets for structure-based ligand discovery.Structure-based drug screening for G-protein-coupled receptorsStructure-function studies with G protein-coupled receptors as a paradigm for improving drug discovery and development of therapeutics.Latest developments in molecular docking: 2010-2011 in review.X-ray structural information of GPCRs in drug design: what are the limitations and where do we go?The histaminergic network in the brain: basic organization and role in disease.Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization.Structure-based and fragment-based GPCR drug discovery.Employing novel animal models in the design of clinically efficacious GPCR ligands.The receptor concept in 3D: from hypothesis and metaphor to GPCR-ligand structures.
P2860
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P2860
Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Crystal structure-based virtua ...... human histamine H(1) receptor
@ast
Crystal structure-based virtua ...... human histamine H(1) receptor
@en
Crystal structure-based virtua ...... human histamine H(1) receptor
@nl
type
label
Crystal structure-based virtua ...... human histamine H(1) receptor
@ast
Crystal structure-based virtua ...... human histamine H(1) receptor
@en
Crystal structure-based virtua ...... human histamine H(1) receptor
@nl
prefLabel
Crystal structure-based virtua ...... human histamine H(1) receptor
@ast
Crystal structure-based virtua ...... human histamine H(1) receptor
@en
Crystal structure-based virtua ...... human histamine H(1) receptor
@nl
P2093
P2860
P50
P3181
P356
P1476
Crystal structure-based virtua ...... human histamine H(1) receptor
@en
P2093
Henry F Vischer
Iwan J P de Esch
Martien Kuijer
Mitsunori Shiroishi
Raymond C Stevens
Tatsuro Shimamura
P2860
P304
P3181
P356
10.1021/JM2011589
P407
P577
2011-12-08T00:00:00Z