Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins
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Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signalStructural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligaseSCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase ItchUbiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysisNedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage responseSelective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMTCalcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibitionRegulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2Ubiquitylation and control of renal Na+ balance and blood pressurePersonalized treatment of Sézary syndrome by targeting a novel CTLA4:CD28 fusion.Ezrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activityHerpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions.The HECT domain of the ubiquitin ligase Rsp5 contributes to substrate recognitionSpartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets.The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease.SIMPLE/LITAF expression induces the translocation of the ubiquitin ligase itch towards the lysosomal compartments.NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes.The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation.The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradationPeptide and small molecule inhibitors of HECT-type ubiquitin ligasesDrosophila Ndfip is a novel regulator of Notch signaling.Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors.Mechanisms of MAVS regulation at the mitochondrial membrane.Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation.The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages.Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cellsAmot130 adapts atrophin-1 interacting protein 4 to inhibit yes-associated protein signaling and cell growth.Regulation of the human ether-a-go-go-related gene (hERG) channel by Rab4 protein through neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2).The ubiquitin ligase adaptor Ndfip1 regulates T cell-mediated gastrointestinal inflammation and inflammatory bowel disease susceptibility.Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells.ATM kinase activity modulates ITCH E3-ubiquitin ligase activity.How ubiquitination regulates the TGF-β signalling pathway: new insights and new players: new isoforms of ubiquitin-activating enzymes in the E1-E3 families join the game.Endosomal transport via ubiquitinationCrosstalk between kinases and Nedd4 family ubiquitin ligases.Multifaceted role of the ubiquitin ligase Itch in immune regulation.The E3 ligase Itch in immune regulation and beyond.
P2860
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P2860
Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins
@ast
Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins
@en
Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins
@nl
type
label
Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins
@ast
Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins
@en
Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins
@nl
prefLabel
Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins
@ast
Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins
@en
Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins
@nl
P2860
P3181
P356
P1433
P1476
Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins
@en
P2093
Hugh R B Pelham
Thomas Mund
P2860
P3181
P356
10.1038/EMBOR.2009.30
P407
P577
2009-05-01T00:00:00Z