Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT
about
Key role for ubiquitin protein modification in TGFβ signal transductionMicroRNA expression characterizes oligometastasis(es)A design principle underlying the paradoxical roles of E3 ubiquitin ligasesKey signaling nodes in mammary gland development and cancer: Smad signal integration in epithelial cell plasticityT Cell Immunoglobulin Mucin Domain (TIM)-3 Promoter Activity in a Human Mast Cell Line.Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent mannerSOX9: a stem cell transcriptional regulator of secreted niche signaling factors.How ubiquitination regulates the TGF-β signalling pathway: new insights and new players: new isoforms of ubiquitin-activating enzymes in the E1-E3 families join the game.Regulation of the transforming growth factor β pathway by reversible ubiquitylation.The physical basis of renal fibrosis: effects of altered hydrodynamic forces on kidney homeostasis.Crosstalk between kinases and Nedd4 family ubiquitin ligases.WWP2: a multifunctional ubiquitin ligase gene.Role of Smad signaling in kidney disease.NFAT3 and TGF-β/SMAD3 regulate the expression of miR-140 in osteoarthritis.MiR-140 is co-expressed with Wwp2-C transcript and activated by Sox9 to target Sp1 in maintaining the chondrocyte proliferation.Characterization of substrate binding of the WW domains in human WWP2 protein.WWP2 ubiquitin ligase and its isoforms: new biological insight and promising disease targets.Paip1, an effective stimulator of translation initiation, is targeted by WWP2 for ubiquitination and degradationImpaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promote tribbles homolog 2 (TRIB2) stability and carcinogenic property in liver cancer.WWP2 is required for normal cell cycle progression.E3 ubiquitin ligases in cancer and implications for therapies.Transforming growth factor-β in stem cells and tissue homeostasis.Disruption of OCT4 Ubiquitination Increases OCT4 Protein Stability and ASH2L-B-Mediated H3K4 Methylation Promoting Pluripotency AcquisitionUbiquitination in Scleroderma Fibrosis and Its Treatment
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P2860
Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Selective targeting of activat ...... ulates TGFβ signalling and EMT
@ast
Selective targeting of activat ...... ulates TGFβ signalling and EMT
@en
Selective targeting of activat ...... ulates TGFβ signalling and EMT
@en-gb
Selective targeting of activat ...... ulates TGFβ signalling and EMT
@nl
type
label
Selective targeting of activat ...... ulates TGFβ signalling and EMT
@ast
Selective targeting of activat ...... ulates TGFβ signalling and EMT
@en
Selective targeting of activat ...... ulates TGFβ signalling and EMT
@en-gb
Selective targeting of activat ...... ulates TGFβ signalling and EMT
@nl
prefLabel
Selective targeting of activat ...... ulates TGFβ signalling and EMT
@ast
Selective targeting of activat ...... ulates TGFβ signalling and EMT
@en
Selective targeting of activat ...... ulates TGFβ signalling and EMT
@en-gb
Selective targeting of activat ...... ulates TGFβ signalling and EMT
@nl
P2860
P356
P1433
P1476
Selective targeting of activat ...... ulates TGFβ signalling and EMT
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2010.617
P407
P577
2011-05-26T00:00:00Z
P5875
P6179
1015905383