A network of multi-tasking proteins at the DNA replication fork preserves genome stability - sprookjes - yvandenbroek - TriplyDB

A network of multi-tasking proteins at the DNA replication fork preserves genome stability

A network of multi-tasking proteins at the DNA replication fork preserves genome stability

http://www.wikidata.org/entity/Q24814638

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Biochemical analysis of human Dna2 Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex Nucleases in homologous recombination as targets for cancer therapy Structural and functional analysis of the Spt16p N-terminal domain reveals overlapping roles of yFACT subunits Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing.Cross talk between the nuclease and helicase activities of Dna2: role of an essential iron-sulfur cluster domain Yeast transcription termination factor Rtt103 functions in DNA damage response Analysis of subunit assembly and function of the Saccharomyces cerevisiae RNase H2 complex.A role for Chd1 and Set2 in negatively regulating DNA replication in Saccharomyces cerevisiae Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation.Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM Dynamic removal of replication protein A by Dna2 facilitates primer cleavage during Okazaki fragment processing in Saccharomyces cerevisiae Interplay of Mre11 nuclease with Dna2 plus Sgs1 in Rad51-dependent recombinational repair.Significance of the dissociation of Dna2 by flap endonuclease 1 to Okazaki fragment processing in Saccharomyces cerevisiae.Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates.Rad52/Rad59-dependent recombination as a means to rectify faulty Okazaki fragment processing.Synthetic cytotoxicity: digenic interactions with TEL1/ATM mutations reveal sensitivity to low doses of camptothecin Evidence suggesting that Pif1 helicase functions in DNA replication with the Dna2 helicase/nuclease and DNA polymerase delta DNA double-strand break repair in Caenorhabditis elegans Complex minisatellite rearrangements generated in the total or partial absence of Rad27/hFEN1 activity occur in a single generation and are Rad51 and Rad52 dependent.Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2.Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing.Yet another job for Dna2: Checkpoint activation.Genetic Regulation of Dna2 Localization During the DNA Damage Response.A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication.RNase H2-initiated ribonucleotide excision repair.Okazaki fragment metabolism.Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability High rates of "unselected" aneuploidy and chromosome rearrangements in tel1 mec1 haploid yeast strains Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends.Dna2 is involved in CA strand resection and nascent lagging strand completion at native yeast telomeres.Hitting the bull's eye: novel directed cancer therapy through helicase-targeted synthetic lethality.Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1.Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability.A saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability Flap endonuclease disengages Dna2 helicase/nuclease from Okazaki fragment flaps.The N-terminal 45-kDa domain of Dna2 endonuclease/helicase targets the enzyme to secondary structure DNA Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication.

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A network of multi-tasking proteins at the DNA replication fork preserves genome stability

http://www.wikidata.org/entity/Q24814638

description

2005 nî lūn-bûn

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2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

A network of multi-tasking pro ...... ork preserves genome stability

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A network of multi-tasking pro ...... ork preserves genome stability

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A network of multi-tasking pro ...... ork preserves genome stability

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type

label

A network of multi-tasking pro ...... ork preserves genome stability

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A network of multi-tasking pro ...... ork preserves genome stability

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A network of multi-tasking pro ...... ork preserves genome stability

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A network of multi-tasking pro ...... ork preserves genome stability

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A network of multi-tasking pro ...... ork preserves genome stability

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A network of multi-tasking pro ...... ork preserves genome stability

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JOURNAL.PGEN.0010061

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A network of multi-tasking pro ...... ork preserves genome stability

@en

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Amy Hin Yan Tong

http://www.w3.org/2001/XMLSchema#string

Charles Boone

http://www.w3.org/2001/XMLSchema#string

Judith L Campbell

http://www.w3.org/2001/XMLSchema#string

Martin E Budd

http://www.w3.org/2001/XMLSchema#string

Piotr Polaczek

http://www.w3.org/2001/XMLSchema#string

Xiao Peng

http://www.w3.org/2001/XMLSchema#string

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The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins

Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2

The characterization of a mammalian DNA structure-specific endonuclease

A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3

Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae

Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication

The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability

The Saccharomyces cerevisiae DNA polymerase alpha catalytic subunit interacts with Cdc68/Spt16 and with Pob3, a protein similar to an HMG1-like protein

Saccharomyces cerevisiae DNA polymerase epsilon and polymerase sigma interact physically and functionally, suggesting a role for polymerase epsilon in sister chromatid cohesion

Crystal structure of a DExx box DNA helicase

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e61

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scholarly article

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3340278

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10.1371/JOURNAL.PGEN.0010061

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6

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1

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2005-12-01T00:00:00Z

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7441352

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16327883

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1298934

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