Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin
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An Overview of Potential Targets for Treating Amyotrophic Lateral Sclerosis and Huntington's DiseaseA small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophyNRF2-regulation in brain health and disease: implication of cerebral inflammationDeficits in bioenergetics and impaired immune response in granulocytes from children with autismAluminium induced endoplasmic reticulum stress mediated cell death in SH-SY5Y neuroblastoma cell line is independent of p53.The biology of proteostasis in aging and disease.Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells.Untargeted metabolic profiling identifies interactions between Huntington's disease and neuronal manganese statusmiR-196a Ameliorates Cytotoxicity and Cellular Phenotype in Transgenic Huntington's Disease Monkey Neural CellsMitochondrial permeability transition pore induces mitochondria injury in Huntington disease.HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease.The emergence of the mitochondrial genome as a partial regulator of nuclear function is providing new insights into the genetic mechanisms underlying age-related complex disease.Quercetin improves the activity of the ubiquitin-proteasomal system in 150Q mutated huntingtin-expressing cells but exerts detrimental effects on neuronal survivability.Mitochondrial membrane fluidity is consistently increased in different models of Huntington disease: restorative effects of olesoxime.KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3) has a key role in the mitochondrial dysfunction induced by mutant huntingtin.Oxidizing effects of exogenous stressors in Huntington's disease knock-in striatal cells--protective effect of cystamine and creatine.Adhesion Regulating Molecule 1 Mediates HAP40 Overexpression-Induced Mitochondrial Defects.Metformin Protects Cells from Mutant Huntingtin Toxicity Through Activation of AMPK and Modulation of Mitochondrial Dynamics.Phycocyanin prevents methylglyoxal-induced mitochondrial-dependent apoptosis in INS-1 cells by Nrf2.Reactive Oxygen Species and Mitochondrial Dynamics: The Yin and Yang of Mitochondrial Dysfunction and Cancer Progression.Evaluation of the Mitochondria-Related Redox and Bioenergetics Effects of Gastrodin in SH-SY5Y Cells Exposed to Hydrogen Peroxide.Dysregulation of Glutamate Cycling Mediates Methylmercury-Induced Neurotoxicity.
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P2860
Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin
description
2013 nî lūn-bûn
@nan
2013 թուականին հրատարակուած գիտական յօդուած
@hyw
2013 թվականին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Impaired mitochondrial dynamic ...... full-length mutant huntingtin
@ast
Impaired mitochondrial dynamic ...... full-length mutant huntingtin
@en
Impaired mitochondrial dynamic ...... full-length mutant huntingtin
@nl
type
label
Impaired mitochondrial dynamic ...... full-length mutant huntingtin
@ast
Impaired mitochondrial dynamic ...... full-length mutant huntingtin
@en
Impaired mitochondrial dynamic ...... full-length mutant huntingtin
@nl
prefLabel
Impaired mitochondrial dynamic ...... full-length mutant huntingtin
@ast
Impaired mitochondrial dynamic ...... full-length mutant huntingtin
@en
Impaired mitochondrial dynamic ...... full-length mutant huntingtin
@nl
P2093
P2860
P3181
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P1476
Impaired mitochondrial dynamic ...... full-length mutant huntingtin
@en
P2093
Chulman Jo
Gail V W Johnson
Soner Gundemir
Yanxun V Yu
Youngnam N Jin
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0057932
P407
P50
P577
2013-01-01T00:00:00Z