HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
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The E3 ubiquitin ligase Hace1 is required for early embryonic development in Xenopus laevis.E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to DegenerationNKX6.3 Regulates Reactive Oxygen Species Production by Suppressing NF-kB and DNMT1 Activities in Gastric Epithelial Cells.Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addictionCoronary artery calcifications predict long term cardiovascular events in non diabetic Caucasian hemodialysis patients.Metformin increases degradation of phospholamban via autophagy in cardiomyocytesToxicogenomics of Phenylhydrazine Induced Hematotoxicity and its Attenuation by Plumbagin from Plumbago zeylanica.HACE1 Negatively Regulates Virus-Triggered Type I IFN Signaling by Impeding the Formation of the MAVS-TRAF3 Complex.The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease: A Mini Review.Oxidative Stress and Huntington's Disease: The Good, The Bad, and The Ugly.Impact of Mediterranean diet on metabolic syndrome, cancer and longevity.Inhibition of cancer antioxidant defense by natural compounds.Tert-buthylhydroquinone pre-conditioning exerts dual effects in old female rats exposed to 3-nitropropionic acid.Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities.Spin Trapping: A Review for the Study of Obesity Related Oxidative Stress and Na+/K+-ATPase.Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?Chronic Progressive Neurodegeneration in a Transgenic Mouse Model of Prion Disease.Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation.HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo.eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response.Myricetin ameliorates brain injury and neurological deficits via Nrf2 activation after experimental stroke in middle-aged rats.Aripiprazole increases NAD(P)H-quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells.Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination.Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities.
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P2860
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 10 February 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
HACE1 reduces oxidative stress ...... y promoting the NRF2 response.
@en
HACE1 reduces oxidative stress ...... y promoting the NRF2 response.
@nl
type
label
HACE1 reduces oxidative stress ...... y promoting the NRF2 response.
@en
HACE1 reduces oxidative stress ...... y promoting the NRF2 response.
@nl
prefLabel
HACE1 reduces oxidative stress ...... y promoting the NRF2 response.
@en
HACE1 reduces oxidative stress ...... y promoting the NRF2 response.
@nl
P2093
P2860
P50
P356
P1476
HACE1 reduces oxidative stress ...... by promoting the NRF2 response
@en
P2093
Adi Barokas
Barak Rotblat
Brian Kwok
Christopher J Carnie
Dieter Fink
Gabriel Leprivier
Gerry Melino
Jason D Galpin
Joan Mathers
P2860
P304
P356
10.1073/PNAS.1314421111
P407
P50
P577
2014-02-10T00:00:00Z