IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid
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Effects of Interferons and Viruses on MetabolismPatterns, Receptors, and Signals: Regulation of Phagosome MaturationMitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.Type II Secretion Is Necessary for Optimal Association of the Legionella-Containing Vacuole with Macrophage Rab1B but Enhances Intracellular Replication Mainly by Rab1B-Independent Mechanisms.Innate Immune Function of Mitochondrial MetabolismThe Roles of Type I Interferon in Bacterial Infection.Inflammasome Recognition and Regulation of the Legionella Flagellum.Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense.Human lung ex vivo infection models.Type I Interferons in Bacterial Infections: A Balancing Act.Role of Dietary Metabolites in Regulating the Host Immune Response in Gastrointestinal Disease.Mitochondria are the powerhouses of immunity.Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection.Krebs cycle rewired for macrophage and dendritic cell effector functions.Mass spectrometry-based proteomic exploration of the human immune system: focus on the inflammasome, global protein secretion, and T cells.Comparative Proteomics of Purified Pathogen Vacuoles Correlates Intracellular Replication of Legionella pneumophila with the Small GTPase Ras-related protein 1 (Rap1).Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection.The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.Towards re-purposing BH3-mimetics in Legionella and viral infections.The cGAS/STING pathway detects Streptococcus pneumoniae but appears dispensable for anti-pneumococcal defense in mice and humans.Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA.The Toolbox for Uncovering the Functions of Legionella Dot/Icm Type IVb Secretion System Effectors: Current State and Future Directions.Proteomics of Mycobacterium Infection: Moving towards a Better Understanding of Pathogen-Driven Immunomodulation.For when bacterial infections persist: Toll-like receptor-inducible direct antimicrobial pathways in macrophages.Metabolic regulation of macrophage phenotype and function.A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation.Soluble mucus component CLCA1 modulates expression of leukotactic cytokines and BPIFA1 in murine alveolar macrophages but not in bone marrow-derived macrophages.Biochemistry of proinflammatory macrophage activation.Metabolic Modulation in Macrophage Effector Function.Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.The type VI secretion system deploys antifungal effectors against microbial competitorsItaconic acid indicates cellular but not systemic immune system activation
P2860
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P2860
IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid
description
2016 nî lūn-bûn
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2016 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2016 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2016年の論文
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年學術文章
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name
IFNs Modify the Proteome of Le ...... Via IRG1-Derived Itaconic Acid
@ast
IFNs Modify the Proteome of Le ...... Via IRG1-Derived Itaconic Acid
@en
IFNs Modify the Proteome of Le ...... Via IRG1-Derived Itaconic Acid
@nl
type
label
IFNs Modify the Proteome of Le ...... Via IRG1-Derived Itaconic Acid
@ast
IFNs Modify the Proteome of Le ...... Via IRG1-Derived Itaconic Acid
@en
IFNs Modify the Proteome of Le ...... Via IRG1-Derived Itaconic Acid
@nl
prefLabel
IFNs Modify the Proteome of Le ...... Via IRG1-Derived Itaconic Acid
@ast
IFNs Modify the Proteome of Le ...... Via IRG1-Derived Itaconic Acid
@en
IFNs Modify the Proteome of Le ...... Via IRG1-Derived Itaconic Acid
@nl
P2093
P2860
P50
P1433
P1476
IFNs Modify the Proteome of Le ...... Via IRG1-Derived Itaconic Acid
@en
P2093
Achim D Gruber
Anca Dorhoi
Andrea Peter
Andreas C Hocke
Bastian Opitz
Christine Hoffmann
Christoph Tabeling
Ian van Driel
Jan Naujoks
Mareike Kunze
P2860
P304
P356
10.1371/JOURNAL.PPAT.1005408
P407
P50
P577
2016-02-01T00:00:00Z