Structural basis of autoregulation of phenylalanine hydroxylase
about
Direct evidence for a phenylalanine site in the regulatory domain of phenylalanine hydroxylaseA new model for allosteric regulation of phenylalanine hydroxylase: implications for disease and therapeuticsRegulation of phenylalanine hydroxylase: conformational changes upon phenylalanine binding detected by hydrogen/deuterium exchange and mass spectrometryInsights into the catalytic mechanisms of phenylalanine and tryptophan hydroxylase from kinetic isotope effects on aromatic hydroxylationRole of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-αStructure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stabilityAn additional substrate binding site in a bacterial phenylalanine hydroxylaseThe Solution Structure of the Regulatory Domain of Tyrosine HydroxylaseCrystal structure of a hypothetical protein, TTHA0829 from Thermus thermophilus HB8, composed of cystathionine-β-synthase (CBS) and aspartate-kinase chorismate-mutase tyrA (ACT) domainsStructural insights into the regulation of aromatic amino acid hydroxylationThe CASTOR Proteins Are Arginine Sensors for the mTORC1 PathwayQueuosine deficiency in eukaryotes compromises tyrosine production through increased tetrahydrobiopterin oxidationMissense mutations in the N-terminal domain of human phenylalanine hydroxylase interfere with binding of regulatory phenylalanineAdaptation of phenylalanine and tyrosine catabolic pathway to hibernation in batsX-ray Scattering Studies of Protein Structural Dynamics.Allosteric Autoinhibition Pathway in Transcription Factor ERG: Dynamics Network and Mutant Experimental Evaluations.Folding dynamics of phenylalanine hydroxylase depends on the enzyme's metallation state: the native metal, iron, protects against aggregate intermediates.Deamidations in recombinant human phenylalanine hydroxylase. Identification of labile asparagine residues and functional characterization of Asn --> Asp mutant forms.Essential role of the N-terminal autoregulatory sequence in the regulation of phenylalanine hydroxylase.A comparison of kinetic and regulatory properties of the tetrameric and dimeric forms of wild-type and Thr427-->Pro mutant human phenylalanine hydroxylase: contribution of the flexible hinge region Asp425-Gln429 to the tetramerization and cooperativPurification, crystallization and crystallographic analysis of Dictyostelium discoideum phenylalanine hydroxylase in complex with dihydrobiopterin and FeIII.Mutagenesis of the regulatory domain of phenylalanine hydroxylase.The non-canonical hydroxylase structure of YfcM reveals a metal ion-coordination motif required for EF-P hydroxylation.Dynamic regulation of phenylalanine hydroxylase by simulated redox manipulationStructures of R- and T-state Escherichia coli aspartokinase III. Mechanisms of the allosteric transition and inhibition by lysine.Phenylalanine hydroxylase misfolding and pharmacological chaperones.The role of rigidity in DNA looping-unlooping by AraCPhenylalanine binding is linked to dimerization of the regulatory domain of phenylalanine hydroxylase.Boosting serotonin in the brain: is it time to revamp the treatment of depression?Activation of phenylalanine hydroxylase by phenylalanine does not require binding in the active siteCharacterization of phenylalanine hydroxylase gene mutations in phenylketonuria in Xinjiang of China.Effects of phosphorylation by protein kinase A on binding of catecholamines to the human tyrosine hydroxylase isoforms.The Amino Acid Specificity for Activation of Phenylalanine Hydroxylase Matches the Specificity for Stabilization of Regulatory Domain Dimers.Crystallization and preliminary X-ray diffraction analysis of prephenate dehydratase from Mycobacterium tuberculosis H37Rv.The ACT domain: a small molecule binding domain and its role as a common regulatory element.First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramerLoss of function in phenylketonuria is caused by impaired molecular motions and conformational instabilityIdentification of the Allosteric Site for Phenylalanine in Rat Phenylalanine Hydroxylase.Impact of quaternary structure dynamics on allosteric drug discovery.Role of the phenylalanine-hydroxylating system in aromatic substance degradation and lipid metabolism in the oleaginous fungus Mortierella alpina
P2860
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P2860
Structural basis of autoregulation of phenylalanine hydroxylase
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Structural basis of autoregulation of phenylalanine hydroxylase
@ast
Structural basis of autoregulation of phenylalanine hydroxylase
@en
Structural basis of autoregulation of phenylalanine hydroxylase
@nl
type
label
Structural basis of autoregulation of phenylalanine hydroxylase
@ast
Structural basis of autoregulation of phenylalanine hydroxylase
@en
Structural basis of autoregulation of phenylalanine hydroxylase
@nl
prefLabel
Structural basis of autoregulation of phenylalanine hydroxylase
@ast
Structural basis of autoregulation of phenylalanine hydroxylase
@en
Structural basis of autoregulation of phenylalanine hydroxylase
@nl
P2093
P3181
P356
P1476
Structural basis of autoregulation of phenylalanine hydroxylase
@en
P2093
B D Santarsiero
B J Michell
I G Jennings
K E Goodwill
R C Stevens
R G Cotton
P2888
P3181
P356
10.1038/8247
P50
P577
1999-05-01T00:00:00Z
P6179
1011254606