Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs
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Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolutionThree-dimensional structures ofDrosophila melanogasteracetylcholinesterase and of its complexes with two potent inhibitorsThree-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugsStructural insights into ligand interactions at the acetylcholinesterase peripheral anionic site.Crystal Structure of Thioflavin T Bound to the Peripheral Site of Torpedo californica Acetylcholinesterase Reveals How Thioflavin T Acts as a Sensitive Fluorescent Reporter of Ligand Binding to the Acylation SiteConformational Remodeling of Femtomolar Inhibitor−Acetylcholinesterase Complexes in the Crystalline StateTargeting Acetylcholinesterase: Identification of Chemical Leads by High Throughput Screening, Structure Determination and Molecular ModelingMolecular characterization of monoclonal antibodies that inhibit acetylcholinesterase by targeting the peripheral site and backdoor regionStructures of Human Acetylcholinesterase Bound to Dihydrotanshinone I and Territrem B Show Peripheral Site FlexibilityA conformational change in the peripheral anionic site of Torpedo californica acetylcholinesterase induced by a bis-imidazolium oximeSubstituent effects on aromatic stacking interactionsDesigning Second Generation Anti-Alzheimer Compounds as Inhibitors of Human Acetylcholinesterase: Computational Screening of Synthetic Molecules and Dietary PhytochemicalsNCI: A server to identify non-canonical interactions in protein structures.PockDrug-Server: a new web server for predicting pocket druggability on holo and apo proteins.An integrated approach with new strategies for QSAR models and lead optimization.Gorge Motions of Acetylcholinesterase Revealed by Microsecond Molecular Dynamics Simulations.Molecular recognition of rosmarinic acid from Salvia sclareoides extracts by acetylcholinesterase: a new binding site detected by NMR spectroscopy.Conformational Preferences of π-π Stacking Between Ligand and Protein, Analysis Derived from Crystal Structure Data Geometric Preference of π-π Interaction.Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.In silico identification of viper phospholipaseA2 inhibitors: validation by in vitro, in vivo studies.Computational discovery and experimental verification of tyrosine kinase inhibitor pazopanib for the reversal of memory and cognitive deficits in rat model neurodegeneration.Design and synthesis of new piperidone grafted acetylcholinesterase inhibitors.Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions.Electron density study of the anti-Alzheimer's disease drug donepezil from conventional x-ray data and invariom database application.Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesteraseAssessing the prospect of donepezil in improving cognitive impairment in patients with schizophrenia.Structure-based search for new inhibitors of cholinesterases.Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India.In vitro acetylcholinesterase inhibition by psoralen using molecular docking and enzymatic studiesRecent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease.Synthesis and in silico evaluation of 1N-methyl-1S-methyl-2-nitroethylene (NMSM) derivatives against Alzheimer disease: to understand their interacting mechanism with acetylcholinesterase.Targeting acetylcholinesterase to treat neurodegeneration.Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics.Fucoxanthin, a Marine Carotenoid, Reverses Scopolamine-Induced Cognitive Impairments in Mice and Inhibits Acetylcholinesterase in VitroEffects of Anticholinesterases on Catalysis and Induced Conformational Change of the Peripheral Anionic Site of Murine AcetylcholinesteraseZephycandidine A, the First Naturally Occurring Imidazo[1,2-f]phenanthridine Alkaloid from Zephyranthes candida, Exhibits Significant Anti-tumor and Anti-acetylcholinesterase Activities.A medicinal chemist's guide to molecular interactionsA compact review on the comparison of conventional and non-conventional interactions on the structural stability of therapeutic proteins.A review on cholinesterase inhibitors for Alzheimer's disease.New pharmacological approaches to the cholinergic system: an overview on muscarinic receptor ligands and cholinesterase inhibitors.
P2860
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P2860
Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Structure of acetylcholinester ...... gn of new anti-Alzheimer drugs
@ast
Structure of acetylcholinester ...... gn of new anti-Alzheimer drugs
@en
Structure of acetylcholinester ...... gn of new anti-Alzheimer drugs
@nl
type
label
Structure of acetylcholinester ...... gn of new anti-Alzheimer drugs
@ast
Structure of acetylcholinester ...... gn of new anti-Alzheimer drugs
@en
Structure of acetylcholinester ...... gn of new anti-Alzheimer drugs
@nl
prefLabel
Structure of acetylcholinester ...... gn of new anti-Alzheimer drugs
@ast
Structure of acetylcholinester ...... gn of new anti-Alzheimer drugs
@en
Structure of acetylcholinester ...... gn of new anti-Alzheimer drugs
@nl
P2093
P3181
P1433
P1476
Structure of acetylcholinester ...... gn of new anti-Alzheimer drugs
@en
P2093
P304
P3181
P356
10.1016/S0969-2126(99)80040-9
P577
1999-03-15T00:00:00Z