Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors
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Evolution of a novel subfamily of nuclear receptors with members that each contain two DNA binding domainsInteractions of SKIP/NCoA-62, TFIIB, and retinoid X receptor with vitamin D receptor helix H10 residuesIdentification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptorElectrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifsThe retinoid X receptors and their ligandsGenomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genomeAbscisic acid regulates inflammation via ligand-binding domain-independent activation of peroxisome proliferator-activated receptor gammaStructure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNAAlternatively spliced isoforms of the human constitutive androstane receptorAlternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptorStructural insights into regulation of nuclear receptors by ligands.Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helixCrystal structure of a mutant hERalpha ligand-binding domain reveals key structural features for the mechanism of partial agonismStructural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptorsThe structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalphaCrystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligandThe three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligandsInsights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligandsCritical role of desolvation in the binding of 20-hydroxyecdysone to the ecdysone receptorT2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding propertiesStructural and Biochemical Basis for the Binding Selectivity of Peroxisome Proliferator-activated Receptor to PGC-1Molecular recognition of nitrated fatty acids by PPARγAtomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligandsStructural basis for the activation of PPARgamma by oxidized fatty acidsAdaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structuresThe nuclear receptor PPARγ individually responds to serotonin- and fatty acid-metabolitesStructure, Energetics, and Dynamics of Binding Coactivator Peptide to the Human Retinoid X Receptor α Ligand Binding Domain Complex with 9- cis -Retinoic AcidThe Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear ReceptorRevealing a steroid receptor ligand as a unique PPARγ agonistMolecular Determinants of Magnolol Targeting Both RXRα and PPARγStructural basis for telmisartan-mediated partial activation of PPAR gammaStructural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRαGQ-16, a Novel Peroxisome Proliferator-activated Receptor (PPAR ) Ligand, Promotes Insulin Sensitization without Weight GainStructural insights into gene repression by the orphan nuclear receptor SHPIdentification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor γ (PPARγ) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetesResveratrol and Its Metabolites Bind to PPARsThe antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolismOn the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal musclesStructure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA
P2860
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P2860
Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors
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2000 nî lūn-bûn
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2000 թուականի Մարտին հրատարակուած գիտական յօդուած
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
@zh-hk
2000年論文
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2000年論文
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name
Asymmetry in the PPARgamma/RXR ...... zation among nuclear receptors
@ast
Asymmetry in the PPARgamma/RXR ...... zation among nuclear receptors
@en
Asymmetry in the PPARgamma/RXR ...... zation among nuclear receptors
@nl
type
label
Asymmetry in the PPARgamma/RXR ...... zation among nuclear receptors
@ast
Asymmetry in the PPARgamma/RXR ...... zation among nuclear receptors
@en
Asymmetry in the PPARgamma/RXR ...... zation among nuclear receptors
@nl
prefLabel
Asymmetry in the PPARgamma/RXR ...... zation among nuclear receptors
@ast
Asymmetry in the PPARgamma/RXR ...... zation among nuclear receptors
@en
Asymmetry in the PPARgamma/RXR ...... zation among nuclear receptors
@nl
P2093
P3181
P1433
P1476
Asymmetry in the PPARgamma/RXR ...... zation among nuclear receptors
@en
P2093
A B Miller
M H Lambert
M V Milburn
R K Bledsoe
S A Kliewer
T M Willson
V G Montana
P304
P3181
P356
10.1016/S1097-2765(00)80448-7
P407
P577
2000-03-01T00:00:00Z