Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
about
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathwayNMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomersFunctional significance of the interaction with Ku in DNA double-strand break recognition of XLFPhosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinaseConversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complexThe E3 ligase RNF8 regulates KU80 removal and NHEJ repairAPLF promotes the assembly and activity of non-homologous end joining protein complexesIn prostate cancer cells the interaction of C/EBPalpha with Ku70, Ku80, and poly(ADP-ribose) polymerase-1 increases sensitivity to DNA damageKu is a 5'-dRP/AP lyase that excises nucleotide damage near broken endsStructural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcsKu86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response elementInvolvement of human polynucleotide kinase in double-strand break repair by non-homologous end joiningSynapsis of DNA ends by DNA-dependent protein kinaseDistribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhereSubnuclear localization of Ku protein: functional association with RNA polymerase II elongation sites.Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminusDynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsEukaryotic DNA ligases: structural and functional insightsStructural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joiningXLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligationRecruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domainCommon mechanisms of PIKK regulationBiochemical evidence for Ku-independent backup pathways of NHEJThe SAF-box domain of chromatin protein DEKDifferential activation of DNA-PK based on DNA strand orientation and sequence biasDNA damage response and Ku80 function in the vertebrate embryo.Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joiningDNA damage and repair in plants - from models to cropsThe role of RecQ helicases in non-homologous end-joiningDNA-PK: a dynamic enzyme in a versatile DSB repair pathwayDNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choiceRecruitment and activation of the ATM kinase in the absence of DNA-damage sensors.Systems modelling of NHEJ reveals the importance of redox regulation of Ku70/80 in the dynamics of dna damage fociAccumulation of DNA damage-induced chromatin alterations in tissue-specific stem cells: the driving force of aging?Solution NMR structure of the N-terminal domain of the human DEK proteinMesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic NeuronsStructure and VP16 binding of the Mediator Med25 activator interaction domainStructure of the VP16 transactivator target in the MediatorThe Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair
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P2860
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Structure of the Ku heterodime ...... for double-strand break repair
@ast
Structure of the Ku heterodime ...... for double-strand break repair
@en
Structure of the Ku heterodime ...... for double-strand break repair
@nl
type
label
Structure of the Ku heterodime ...... for double-strand break repair
@ast
Structure of the Ku heterodime ...... for double-strand break repair
@en
Structure of the Ku heterodime ...... for double-strand break repair
@nl
prefLabel
Structure of the Ku heterodime ...... for double-strand break repair
@ast
Structure of the Ku heterodime ...... for double-strand break repair
@en
Structure of the Ku heterodime ...... for double-strand break repair
@nl
P2093
P3181
P356
P1433
P1476
Structure of the Ku heterodime ...... or double-strand break repair.
@en
P2093
J Goldberg
J R Walker
R A Corpina
P2888
P304
P3181
P356
10.1038/35088000
P407
P577
2001-08-09T00:00:00Z
P6179
1004170107