De novo design, synthesis, and in vitro evaluation of inhibitors for prokaryotic tRNA-guanine transglycosylase: a dramatic sulfur effect on binding affinity
about
Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug designApplication of the PM6 semi-empirical method to modeling proteins enhances docking accuracy of AutoDockSynthesis and phenotypic screening of a Guanine-mimetic library.Rapid comparison of protein binding site surfaces with property encoded shape distributionsMechanism and substrate specificity of tRNA-guanine transglycosylases (TGTs): tRNA-modifying enzymes from the three different kingdoms of life share a common catalytic mechanism.Merging allosteric and active site binding motifs: de novo generation of target selectivity and potency via natural-product-derived fragments.Bisubstrate inhibitors for the enzyme catechol-O-methyltransferase (COMT): influence of inhibitor preorganisation and linker length between the two substrate moieties on binding affinity.A New Class of Inhibitors for the Metalloprotease Neprilysin Based on a Central Imidazole Scaffold
P2860
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P2860
De novo design, synthesis, and in vitro evaluation of inhibitors for prokaryotic tRNA-guanine transglycosylase: a dramatic sulfur effect on binding affinity
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2002 nî lūn-bûn
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2002 թուականի Մարտին հրատարակուած գիտական յօդուած
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2002 թվականի մարտին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年论文
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name
De novo design, synthesis, and ...... fur effect on binding affinity
@ast
De novo design, synthesis, and ...... fur effect on binding affinity
@en
De novo design, synthesis, and ...... fur effect on binding affinity
@nl
type
label
De novo design, synthesis, and ...... fur effect on binding affinity
@ast
De novo design, synthesis, and ...... fur effect on binding affinity
@en
De novo design, synthesis, and ...... fur effect on binding affinity
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prefLabel
De novo design, synthesis, and ...... fur effect on binding affinity
@ast
De novo design, synthesis, and ...... fur effect on binding affinity
@en
De novo design, synthesis, and ...... fur effect on binding affinity
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P50
P1433
P1476
De novo design, synthesis, and ...... fur effect on binding affinity
@en
P2093
Emmanuel A Meyer
Maya Furler
P356
10.1002/1439-7633(20020301)3:2/3<250::AID-CBIC250>3.0.CO;2-J
P577
2002-03-01T00:00:00Z