Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design

Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design

Item
http://www.wikidata.org/entity/Q27642266
Glutamate versus Glutamine Exchange Swaps Substrate Selectivity in tRNA-Guanine Transglycosylase: Insight into the Regulation of Substrate Selectivity by Kinetic and Crystallographic StudiesHow to replace the residual solvation shell of polar active site residues to achieve nanomolar inhibition of tRNA-guanine transglycosylaseInvestigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as InhibitorFrom lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clustersSoaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibitionThe role of aspartic acid 143 in E. coli tRNA-guanine transglycosylase: insights from mutagenesis studies and computational modeling.Homologous ligands accommodated by discrete conformations of a buried cavity.The queuine micronutrient: charting a course from microbe to man.Mechanism and substrate specificity of tRNA-guanine transglycosylases (TGTs): tRNA-modifying enzymes from the three different kingdoms of life share a common catalytic mechanism.The PUA domain - a structural and functional overview.Molecular recognition in chemical and biological systems.Crystal Structure of the Human tRNA Guanine Transglycosylase Catalytic Subunit QTRT1
P2860

Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design

Item
http://www.wikidata.org/entity/Q27642266
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Flexible adaptations in the st ...... nd structure-based drug design
@ast
Flexible adaptations in the st ...... nd structure-based drug design
@en
Flexible adaptations in the st ...... nd structure-based drug design
@nl
type
label
Flexible adaptations in the st ...... nd structure-based drug design
@ast
Flexible adaptations in the st ...... nd structure-based drug design
@en
Flexible adaptations in the st ...... nd structure-based drug design
@nl
prefLabel
Flexible adaptations in the st ...... nd structure-based drug design
@ast
Flexible adaptations in the st ...... nd structure-based drug design
@en
Flexible adaptations in the st ...... nd structure-based drug design
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P921
P356
P1433
P1476
Flexible adaptations in the st ...... nd structure-based drug design
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P921