Structural origins of the functional divergence of human insulin-like growth factor-I and insulin
about
Alanine scanning of a putative receptor binding surface of insulin-like growth factor-IHarmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activationAn automatic refolding apparatus for preparative-scale protein productionDesign of an Insulin Analog with Enhanced Receptor Binding Selectivity: RATIONALE, STRUCTURE, AND THERAPEUTIC IMPLICATIONSCrystal Structure of a"Nonfoldable"Insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITYProtective hinge in insulin opens to enable its receptor engagementEnsemble MD simulations restrained via crystallographic data: accurate structure leads to accurate dynamicsAromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.Insulin-like growth factor binding proteins: a structural perspective.Proinsulin is refractory to protein fibrillation: topological protection of a precursor protein from cross-beta assembly.Insulin/receptor binding: the last piece of the puzzle? What recent progress on the structure of the insulin/receptor complex tells us (or not) about negative cooperativity and activation.Characterization of inhibitory anti-insulin-like growth factor receptor antibodies with different epitope specificity and ligand-blocking properties: implications for mechanism of action in vivo.Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family.Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?Contact-based sequence alignment.Three-dimensional structural interactions of insulin and its receptor.Elucidating the Activation Mechanism of the Insulin-Family Proteins with Molecular Dynamics Simulations.Downregulation of Signaling-active IGF-1 by Dipeptidyl Peptidase IV (DPP-IV)Obesity, diabetes and cancer: insight into the relationship from a cohort with growth hormone receptor deficiency.Theoretical and computational studies of peptides and receptors of the insulin family.Improving expression of recombinant human IGF-1 using IGF-1R knockout CHO cell lines.Large-scale analysis of variation in the insulin-like growth factor family in humans reveals rare disease links and common polymorphisms.Effects of insulin-like growth factor-1 on B-cell precursor acute lymphoblastic leukemia.A conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog.Mapping of the insulin-like growth factor II binding site of the Type I insulin-like growth factor receptor by alanine scanning mutagenesis.Structural Perspectives of Insulin Receptor Isoform-Selective Insulin Analogs.Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain.Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.Peptide models of four possible insulin folding intermediates with two disulfides.Effects of insulin-like growth factor I on alveolar bone remodeling in diabetic rats.Endosomal proteolysis of insulin-like growth factor-I at its C-terminal D-domain by cathepsin B.An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein.Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding.How ligand binds to the type 1 insulin-like growth factor receptor.A Novel Binding Site for the Human Insulin-like Growth Factor-II (IGF-II)/Mannose 6-Phosphate Receptor on IGF-IIStructures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones
P2860
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P2860
Structural origins of the functional divergence of human insulin-like growth factor-I and insulin
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Structural origins of the func ...... ke growth factor-I and insulin
@ast
Structural origins of the func ...... ke growth factor-I and insulin
@en
Structural origins of the func ...... ke growth factor-I and insulin
@nl
type
label
Structural origins of the func ...... ke growth factor-I and insulin
@ast
Structural origins of the func ...... ke growth factor-I and insulin
@en
Structural origins of the func ...... ke growth factor-I and insulin
@nl
prefLabel
Structural origins of the func ...... ke growth factor-I and insulin
@ast
Structural origins of the func ...... ke growth factor-I and insulin
@en
Structural origins of the func ...... ke growth factor-I and insulin
@nl
P2093
P3181
P356
P1433
P1476
Structural origins of the func ...... ke growth factor-I and insulin
@en
P2093
Andrzej M Brzozowski
Chandra Verma
Eleanor J Dodson
Frederik M de Bree
Garib N Murshudov
Guy G Dodson
P304
P3181
P356
10.1021/BI020084J
P407
P577
2002-07-30T00:00:00Z