Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes
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Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19Structure of the human lung cytochrome P450 2A13Structural characterization of the complex between alpha-naphthoflavone and human cytochrome P450 1B1Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokersStructural diversity of eukaryotic membrane cytochrome p450sCrystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoKAn open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolutionStructure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding siteCrystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1 H -imidazole: Ligand-Induced Structural Response through α-Helical Repositioning ,Structural Analysis of CYP101C1 from Novosphingobium aromaticivorans DSM12444Crystal Structure of Human Cytochrome P450 2D6 with Prinomastat BoundRecalling P446. P4501A1 (CYP1A1) opting for clinical applicationStructural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.Binding of 7-methoxy-4-(aminomethyl)-coumarin to wild-type and W128F mutant cytochrome P450 2D6 studied by time-resolved fluorescence spectroscopyThe structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution.Molecular dynamics analysis reveals structural insights into mechanism of nicotine N-demethylation catalyzed by tobacco cytochrome P450 mono-oxygenase[Metabolism of xenobiotics: beneficial and adverse effects].Do mammalian cytochrome P450s show multiple ligand access pathways and ligand channelling?Structural motif-based homology modeling of CYP27A1 and site-directed mutational analyses affecting vitamin D hydroxylation.Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET.New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.Simultaneous measurement of CYP1A2 activity, regioselectivity, and coupling: Implications for environmental sensitivity of enzyme-substrate binding.Cytochrome P450: what have we learned and what are the future issues?Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.Unusual regioselectivity and active site topology of human cytochrome P450 2J2Gates of enzymes.A novel 9-bp insertion detected in steroid 21-hydroxylase gene (CYP21A2): prediction of its structural and functional implications by computational methods.Studies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11Substrate binding to cytochromes P450.Cooperative properties of cytochromes P450.Human P450s involved in drug metabolism and the use of structural modelling for understanding substrate selectivity and binding affinity.Conformational plasticity and structure/function relationships in cytochromes P450.Cytochrome P450 1A1-mediated anticancer drug discovery: in silico findings.Conformational diversity and ligand tunnels of mammalian cytochrome P450s.State-of-the-art tools for computational site of metabolism predictions: comparative analysis, mechanistical insights, and future applications.Remarkable substrate-specificity of CYP6AB3 in Depressaria pastinacella, a highly specialized caterpillar.Three-dimensional models of wild-type and mutated forms of cytochrome P450 14alpha-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding.Conformational equilibrium of cytochrome P450 BM-3 complexed with N-palmitoylglycine: a replica exchange molecular dynamics study.Hybrid homology modeling and mutational analysis of cytochrome P450C24A1 (CYP24A1) of the Vitamin D pathway: insights into substrate specificity and membrane bound structure-functionFree energies of binding of R- and S-propranolol to wild-type and F483A mutant cytochrome P450 2D6 from molecular dynamics simulations
P2860
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P2860
Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Structure of a substrate compl ...... ltiple substrate binding modes
@ast
Structure of a substrate compl ...... ltiple substrate binding modes
@en
Structure of a substrate compl ...... ltiple substrate binding modes
@nl
type
label
Structure of a substrate compl ...... ltiple substrate binding modes
@ast
Structure of a substrate compl ...... ltiple substrate binding modes
@en
Structure of a substrate compl ...... ltiple substrate binding modes
@nl
prefLabel
Structure of a substrate compl ...... ltiple substrate binding modes
@ast
Structure of a substrate compl ...... ltiple substrate binding modes
@en
Structure of a substrate compl ...... ltiple substrate binding modes
@nl
P2093
P356
P1433
P1476
Structure of a substrate compl ...... ltiple substrate binding modes
@en
P2093
C David Stout
Cristina Marques-Soares
Eric F Johnson
Michael R Wester
Patrick M Dansette
P304
P356
10.1021/BI0273922
P407
P577
2003-06-03T00:00:00Z