Insights into the Conformational Variability and Regulation of Human Nek2 Kinase - sprookjes - yvandenbroek - TriplyDB

Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

http://www.wikidata.org/entity/Q27653344

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Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9 Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural Characterization The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase Crystal Structures of Human CaMKIα Reveal Insights into the Regulation Mechanism of CaMKI Molecular Features of Product Release for the PKA Catalytic Cycle A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase The Toxoplasma gondii centrosome is the platform for internal daughter budding as revealed by a Nek1 kinase mutant Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain.NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin.Characterization of acute renal allograft rejection by proteomic analysis of renal tissue in rat.The BioAssay network and its implications to future therapeutic discovery.Therapeutic melting pot of never in mitosis gene a related kinase 2 (Nek2): a perspective on Nek2 as an oncology target and recent advancements in Nek2 small molecule inhibition Inhibition of Nek2 by small molecules affects proteasome activity.Structure-guided design of purine-based probes for selective Nek2 inhibition Centrosomal kinase Nek2 cooperates with oncogenic pathways to promote metastasis Cancerous inhibitor of protein phosphatase 2A (CIP2A) protein is involved in centrosome separation through the regulation of NIMA (never in mitosis gene A)-related kinase 2 (NEK2) protein activity.Cell cycle regulation by the NEK family of protein kinases.On the molecular mechanisms of mitotic kinase activation.The structural mechanisms that underpin mitotic kinase activation.Structure-functional prediction and analysis of cancer mutation effects in protein kinases.Nek2A contributes to tumorigenic growth and possibly functions as potential therapeutic target for human breast cancer.Identification by high-throughput screening of viridin analogs as biochemical and cell-based inhibitors of the cell cycle-regulated nek2 kinase.Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization.Mitotic Regulation by NEK Kinase Networks.A kinetic test characterizes kinase intramolecular and intermolecular autophosphorylation mechanisms.Abnormal expression of Nek2 and β-catenin in breast carcinoma: clinicopathological correlations.Kinase inhibitor profile for human nek1, nek6, and nek7 and analysis of the structural basis for inhibitor specificity.Identification and antitumor activity of a novel inhibitor of the NIMA-related kinase NEK6

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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

http://www.wikidata.org/entity/Q27653344

description

2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

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J.JMB.2008.12.033

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Journal of Molecular Biology

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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

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Andrew M Fry

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Donna-Marie Cheary

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Isaac Westwood

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Joanne E Baxter

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Rob L M van Montfort

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P2860

NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1

Structural basis of Aurora-A activation by TPX2 at the mitotic spindle

C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2

Rootletin forms centriole-associated filaments and functions in centrosome cohesion

Mitotic regulation by NIMA-related kinases

Structure and regulation of the human Nek2 centrosomal kinase

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

Three-dimensional structure of the tyrosine kinase c-Src

Crystal structure of the Src family tyrosine kinase Hck

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Richard Bayliss

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