about
Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domainCoordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle bindingThe importance of occupancy rather than affinity of CaV(beta) subunits for the calcium channel I-II linker in relation to calcium channel functionMolecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugsInsights into the Conformational Variability and Regulation of Human Nek2 KinaseA Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome CondensationAn Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug designStructural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR)Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domainThe HOOK-domain between the SH3 and the GK domains of Cavbeta subunits contains key determinants controlling calcium channel inactivation.Molecular mechanisms of human IRE1 activation through dimerization and ligand bindingStructural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors.Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.Ca2+ channel beta-subunits: structural insights AID our understanding.A closed conformation of the Caenorhabditis elegans separase-securin complex.Differential protein stability and clinical responses of EML4-ALK fusion variants to various ALK inhibitors in advanced ALK-rearranged non-small cell lung cancer.A moving target: structure and disorder in pursuit of Myc inhibitors.Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain.Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization.Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.Phosphorylation sites on calcium channel alpha1 and beta subunits regulate ERK-dependent modulation of neuronal N-type calcium channels.Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex.Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix.Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate releaseMitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression
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description
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P1153
56354192800
P21
P31
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0000-0003-1108-2825