Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design - sprookjes - yvandenbroek - TriplyDB

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design

http://www.wikidata.org/entity/Q27654001

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Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate The G protein α chaperone Ric-8 as a potential therapeutic target Functional analysis of Hsp70 inhibitors Structure of the 34 kDa F-actin-bundling protein ABP34 from Dictyostelium discoideum Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.The human HSP70 family of chaperones: where do we stand?Selective targeting of the stress chaperome as a therapeutic strategy Allostery in the Hsp70 chaperone proteins rDock: a fast, versatile and open source program for docking ligands to proteins and nucleic acids Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells.The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells A novel Hsp70 inhibitor prevents cell intoxication with the actin ADP-ribosylating Clostridium perfringens iota toxin HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.Heat shock protein responses to aging and proteotoxicity in the olfactory bulb.Small molecule DnaK modulators targeting the beta-domain.High-throughput screening for modulators of protein-protein interactions: use of photonic crystal biosensors and complementary technologies.Integrating surface plasmon resonance biosensor-based interaction kinetic analyses into the lead discovery and optimization process.Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation Heat shock protein 70 (hsp70) as an emerging drug target.Protein chaperones: a composition of matter review (2008 - 2013).Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.Fear conditioning leads to alteration in specific genes expression in cortical and thalamic neurons that project to the lateral amygdala.Heat shock protein defenses in the neocortex and allocortex of the telencephalon.Heat-induced ribosome pausing triggers mRNA co-translational decay in Arabidopsis thaliana.The Chemical Biology of Molecular Chaperones--Implications for Modulation of Proteostasis Heat shock protein 70 regulates platelet integrin activation, granule secretion and aggregation.A cotranslational ubiquitination pathway for quality control of misfolded proteins.Fluorescent ligand for human progesterone receptor imaging in live cells.The HSP70 family and cancer Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules.Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition.Pharmacological targeting of the Hsp70 chaperone.A medicinal chemist's guide to molecular interactions Hsp70 protein complexes as drug targets.Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70 Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.Targeting Hsp70: A possible therapy for cancer.

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Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design

http://www.wikidata.org/entity/Q27654001

description

2009 nî lūn-bûn

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2009 թուականի Մարտին հրատարակուած գիտական յօդուած

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2009 թվականի մարտին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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name

Novel adenosine-derived inhibi ...... through structure-based design

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Novel adenosine-derived inhibi ...... through structure-based design

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Novel adenosine-derived inhibi ...... through structure-based design

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Novel adenosine-derived inhibi ...... through structure-based design

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Novel adenosine-derived inhibi ...... through structure-based design

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Novel adenosine-derived inhibi ...... through structure-based design

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Novel adenosine-derived inhibi ...... through structure-based design

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Novel adenosine-derived inhibi ...... through structure-based design

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Journal of Medicinal Chemistry

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Novel adenosine-derived inhibi ...... through structure-based design

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Alexandra Clay

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Allan E Surgenor

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Andrew J Massey

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Christopher J Graham

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Geraint L Francis

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James B Murray

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Jenifer Borgognoni

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Lindsey Terry

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Martin J Drysdale

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Mike Wood

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scholarly article

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3096571

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10.1021/JM801627A

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6

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Douglas S. Williamson

Nicolas Foloppe

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2009-03-01T00:00:00Z

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24172858

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19256508

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