Selective targeting of the stress chaperome as a therapeutic strategy
about
Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94Mechanistic Asymmetry in Hsp90 DimersRegulation and function of the human HSP90AA1 geneBlocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains.Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes.Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas.Surprising origins of sex differences in the brain.Hallmarks of therapeutic management of the cystic fibrosis functional landscape.A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 SpeciesCombinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas.Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease.Clients Place Unique Functional Constraints on Hsp90.Stressing Out Hsp90 in Neurotoxic Proteinopathies.Heat Shock Protein (HSP) Drug Discovery and Development: Targeting Heat Shock Proteins in Disease.BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells.Natural Product Inspired N-Terminal Hsp90 Inhibitors: From Bench to Bedside?HSP90 inhibitors in the context of heat shock and the unfolded protein response: effects on a primary canine pulmonary adenocarcinoma cell line.The epichaperome is an integrated chaperome network that facilitates tumour survivalRNAi Screening of the Glucose-Regulated Chaperones in Cancer with Self-Assembled siRNA Nanostructures.Targeting the Diabetic Chaperome to Improve Peripheral Neuropathy.Therapeutic implication of concomitant chromosomal aberrations in patients with aggressive B-cell lymphomasOverexpression of hsp27 Rescued Neuronal Cell Death and Reduction in Life- and Health-Span in Drosophila melanogaster Against Prolonged Exposure to Dichlorvos.Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer.Proteomic interrogation of HSP90 and insights for medical research.Bag1 Co-chaperone Promotes TRC8 E3 Ligase-dependent Degradation of Misfolded Human Ether a Go-Go-related Gene (hERG) Potassium Channels.First-in-human study of the epichaperome inhibitor PU-H71: clinical results and metabolic profile.Discovery of new molecular entities able to strongly interfere with Hsp90 C-terminal domain.Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma.HSP90 stabilizes B-cell receptor kinases in a multi-client interactome: PU-H71 induces CLL apoptosis in a cytoprotective microenvironment.Targeting the Proteostasis Network for Mycobacterial Drug Discovery.Adapting to stress - chaperome networks in cancer.Repurposing drugs to target the malaria parasite unfolding protein response.The Nuclear Receptor Field: A Historical Overview and Future ChallengesHSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neuronsThe HSP90 Family: Structure, Regulation, Function, and Implications in Health and DiseaseHeat Shock Proteins in Alzheimer's Disease: Role and TargetingQuaternary structures of GroEL and naïve-Hsp60 chaperonins in solution: a combined SAXS-MD study
P2860
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P2860
Selective targeting of the stress chaperome as a therapeutic strategy
description
2014 nî lūn-bûn
@nan
2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
name
Selective targeting of the stress chaperome as a therapeutic strategy
@ast
Selective targeting of the stress chaperome as a therapeutic strategy
@en
Selective targeting of the stress chaperome as a therapeutic strategy
@nl
type
label
Selective targeting of the stress chaperome as a therapeutic strategy
@ast
Selective targeting of the stress chaperome as a therapeutic strategy
@en
Selective targeting of the stress chaperome as a therapeutic strategy
@nl
prefLabel
Selective targeting of the stress chaperome as a therapeutic strategy
@ast
Selective targeting of the stress chaperome as a therapeutic strategy
@en
Selective targeting of the stress chaperome as a therapeutic strategy
@nl
P2860
P1476
Selective targeting of the stress chaperome as a therapeutic strategy
@en
P2093
Pallav D Patel
Stefan O Ochiana
P2860
P304
P356
10.1016/J.TIPS.2014.09.001
P407
P577
2014-11-01T00:00:00Z