The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain
about
Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamicsStructural basis of cargo recognition by the myosin-X MyTH4-FERM domainStructural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteinsSHARPIN is an endogenous inhibitor of β1-integrin activationA practical guide to small angle X-ray scattering (SAXS) of flexible and intrinsically disordered proteinsIntegrin cytoplasmic tail interactionsThe talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clusteringMembrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin ActivationRIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and TurnoverStructural Basis for Small G Protein Effector Interaction of Ras-related Protein 1 (Rap1) and Adaptor Protein Krev Interaction Trapped 1 (KRIT1)The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanismA novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesionPIP kinases define PI4,5P₂signaling specificity by association with effectorsTalin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis.Talins and kindlins: partners in integrin-mediated adhesion.New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.The talin dimer structure orientation is mechanically regulated.Membrane-induced structural rearrangement and identification of a novel membrane anchor in talin F2F3The tail of integrin activation.Conformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helicesThe integrin-linked kinase-PINCH-parvin complex supports integrin αIIbβ3 activation.Multiscale simulations suggest a mechanism for integrin inside-out activation.The C terminus of talin links integrins to cell cycle progression.Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment.A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.Efficient Exploration of Membrane-Associated Phenomena at Atomic Resolution.Subcellular localization of talin is regulated by inter-domain interactionsTalin activates integrins by altering the topology of the β transmembrane domainLeukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activationAtomic-level description of protein-lipid interactions using an accelerated membrane model.Myosin MyTH4-FERM structures highlight important principles of convergent evolution.The mechanical response of talin.On the activation of integrin αIIbβ3: outside-in and inside-out pathways.Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation.Integrins: versatile receptors controlling melanocyte adhesion, migration and proliferation.Molecular mechanism of inside-out integrin regulationStructural analysis of intrinsically disordered proteins by small-angle X-ray scattering.The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties.Mechanisms of talin-dependent integrin signaling and crosstalk
P2860
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P2860
The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain
@ast
The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain
@en
The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain
@nl
type
label
The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain
@ast
The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain
@en
The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain
@nl
prefLabel
The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain
@ast
The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain
@en
The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain
@nl
P2093
P2860
P3181
P1433
P1476
The Structure of the talin head reveals a novel extended conformation of the FERM domain
@en
P2093
David R Critchley
Igor L Barsukov
J Günter Grossmann
Paul R Elliott
Petra M Kopp
P2860
P304
P3181
P356
10.1016/J.STR.2010.07.011
P577
2010-10-01T00:00:00Z