Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber
about
Human TRiC complex purified from HeLa cells contains all eight CCT subunits and is active in vitroProgrammed cell death protein 5 interacts with the cytosolic chaperonin containing tailless complex polypeptide 1 (CCT) to regulate β-tubulin foldingChemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosisTherapeutic Approaches for Inhibition of Protein Aggregation in Huntington's DiseaseThe dynamic conformational cycle of the group I chaperonin C-termini revealed via molecular dynamics simulationATP dependent rotational motion of group II chaperonin observed by X-ray single molecule trackingCryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure.Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle.Mechanism of nucleotide sensing in group II chaperoninsFlexible interwoven termini determine the thermal stability of thermosomesThe molecular architecture of the eukaryotic chaperonin TRiC/CCTInteraction of p53 with the CCT complex promotes protein folding and wild-type p53 activityDynamics, flexibility, and allostery in molecular chaperoninsThe structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCTDesign of Light-Controlled Protein Conformations and FunctionsReprogramming an ATP-driven protein machine into a light-gated nanocageMultiscale natural moves refine macromolecules using single-particle electron microscopy projection imagesAsymmetry in the function and dynamics of the cytosolic group II chaperonin CCT/TRiCSequential allosteric mechanism of ATP hydrolysis by the CCT/TRiC chaperone is revealed through Arrhenius analysisStructure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy.A human CCT5 gene mutation causing distal neuropathy impairs hexadecamer assembly in an archaeal model.Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly.A gradient of ATP affinities generates an asymmetric power stroke driving the chaperonin TRIC/CCT folding cycle.Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers.Characterization of group II chaperonins from an acidothermophilic archaeon Picrophilus torridus.The ribosome as a hub for protein quality control.Opportunities and challenges for molecular chaperone modulation to treat protein-conformational brain diseasesThe Mechanism and Function of Group II Chaperonins.High Expression of Cell Division Cycle 42 Promotes Pancreatic Cancer Growth and Predicts Poor Outcome of Pancreatic Cancer Patients.Evolution of the archaeal and mammalian information processing systems: towards an archaeal model for human disease.Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM.Chaperone-client interactions: Non-specificity engenders multifunctionality.Group II archaeal chaperonin recognition of partially folded human γD-crystallin mutantsAn information theoretic framework reveals a tunable allosteric network in group II chaperonins.Surface Engineering of Nanoparticles for Targeted Delivery to Hepatocellular Carcinoma.Intraring allostery controls the function and assembly of a hetero-oligomeric class II chaperonin.Using the dendritic polymer PAMAM to form gold nanoparticles in the protein cage thermosome.Time-Resolved Measurement of the ATP-Dependent Motion of the Group II Chaperonin by Diffracted Electron Tracking.Structural investigation of a chaperonin in action reveals how nucleotide binding regulates the functional cycleMolecular determinants of the ATP hydrolysis asymmetry of the CCT chaperonin complex
P2860
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P2860
Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Dual Action of ATP Hydrolysis ...... he Group II Chaperonin Chamber
@ast
Dual Action of ATP Hydrolysis ...... he Group II Chaperonin Chamber
@en
Dual Action of ATP Hydrolysis ...... he Group II Chaperonin Chamber
@nl
type
label
Dual Action of ATP Hydrolysis ...... he Group II Chaperonin Chamber
@ast
Dual Action of ATP Hydrolysis ...... he Group II Chaperonin Chamber
@en
Dual Action of ATP Hydrolysis ...... he Group II Chaperonin Chamber
@nl
prefLabel
Dual Action of ATP Hydrolysis ...... he Group II Chaperonin Chamber
@ast
Dual Action of ATP Hydrolysis ...... he Group II Chaperonin Chamber
@en
Dual Action of ATP Hydrolysis ...... he Group II Chaperonin Chamber
@nl
P2093
P2860
P3181
P1433
P1476
Dual Action of ATP Hydrolysis ...... he Group II Chaperonin Chamber
@en
P2093
Joanita Jakana
Junjie Zhang
Nicholai R Douglas
Ramya Kumar
Stefanie Reissmann
P2860
P304
P3181
P356
10.1016/J.CELL.2010.12.017
P407
P577
2011-01-21T00:00:00Z