Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity
about
Chaperonin-containing TCP-1 complex directly binds to the cytoplasmic domain of the LOX-1 receptorContribution of the Type II Chaperonin, TRiC/CCT, to OncogenesisCancer's Achilles' Heel: Apoptosis and Necroptosis to the RescueThe structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCTFunctional interplay between MDM2, p63/p73 and mutant p53Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer.Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation.Modulation of STAT3 folding and function by TRiC/CCT chaperonin.Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a ∆133p53α mimic.Structural Basis for Modulation of Quality Control Fate in a Marginally Stable Protein.Overexpression of chaperonin containing TCP1, subunit 3 predicts poor prognosis in hepatocellular carcinomaBAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function.Down-regulation of LATS kinases alters p53 to promote cell migration.Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO.Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions.Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan.Mutant p53 in cancer: new functions and therapeutic opportunities.Pharmacological reactivation of p53 as a strategy to treat cancer.The Mechanism and Function of Group II Chaperonins.Mutant p53 upregulates alpha-1 antitrypsin expression and promotes invasion in lung cancer.p53 and its mutants on the slippery road from stemness to carcinogenesis.The Paradox of p53: What, How, and Why?Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy.Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM.SMG7 is a critical regulator of p53 stability and function in DNA damage stress response.Chaperonin Containing TCP-1 Protein Level in Breast Cancer Cells Predicts Therapeutic Application of a Cytotoxic Peptide.Chaperonin containing TCP1 subunit 5 is a tumor associated antigen of non-small cell lung cancer.Isg15 controls p53 stability and functions.Disrupting CCT-β : β-tubulin selectively kills CCT-β overexpressed cancer cells through MAPKs activation.p53 shades of Hippo.Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells.Chaperonin containing TCP-1 subunit 3 is critical for gastric cancer growth.Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family.Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone)TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A.Comprehensive transcriptomic analysis of heat shock proteins in the molecular subtypes of human breast cancer.
P2860
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P2860
Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Interaction of p53 with the CC ...... ing and wild-type p53 activity
@ast
Interaction of p53 with the CC ...... ing and wild-type p53 activity
@en
Interaction of p53 with the CC ...... ng and wild-type p53 activity.
@nl
type
label
Interaction of p53 with the CC ...... ing and wild-type p53 activity
@ast
Interaction of p53 with the CC ...... ing and wild-type p53 activity
@en
Interaction of p53 with the CC ...... ng and wild-type p53 activity.
@nl
altLabel
Interaction of p53 with the CC ...... ing and wild-type p53 activity
@en
prefLabel
Interaction of p53 with the CC ...... ing and wild-type p53 activity
@ast
Interaction of p53 with the CC ...... ing and wild-type p53 activity
@en
Interaction of p53 with the CC ...... ng and wild-type p53 activity.
@nl
P2093
P2860
P50
P1433
P1476
Interaction of p53 with the CC ...... ing and wild-type p53 activity
@en
P2093
Antonio Garcia Trinidad
Karen H Vousden
Marta Klejnot
Patricia A J Muller
P2860
P304
P356
10.1016/J.MOLCEL.2013.05.002
P407
P577
2013-06-06T00:00:00Z