The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases - sprookjes - yvandenbroek - TriplyDB

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

http://www.wikidata.org/entity/Q27667409

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Association of global DNA methylation and global DNA hydroxymethylation with metals and other exposures in human blood DNA samples Gatekeepers of chromatin: Small metabolites elicit big changes in gene expression Links between metabolism and cancer Clinical significance of T cell metabolic reprogramming in cancer Fundamentals of cancer metabolism Mitochondrial metabolic remodeling in response to genetic and environmental perturbations Epigenetic regulators and their impact on therapy in acute myeloid leukemia Dysregulated metabolism contributes to oncogenesis Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics New developments in the pathogenesis and therapeutic targeting of the IDH1 mutation in glioma Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma Molecular biology of gliomas: present and future challenges Genetically-defined metabolic reprogramming in cancer Novel therapeutic targets of tumor metabolism KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells Chromatin signatures of cancer Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases Structures of Human ALKBH5 Demethylase Reveal a Unique Binding Mode for Specific Single-stranded N 6 -Methyladenosine RNA Demethylation Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation IDH mutations in tumorigenesis and their potential role as novel therapeutic targets.Defects in mitochondrial metabolism and cancer A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma.IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives Metabolic rewiring in melanoma Oncometabolites: Unconventional triggers of oncogenic signalling cascades Undercover: gene control by metabolites and metabolic enzymes Metabolic control of cancer cell stemness: Lessons from iPS cells The mitochondrial side of epigenetics Metabolic consequences of oncogenic IDH mutations Oncometabolites: tailoring our genes 2-Hydoxyglutarate: D/Riving Pathology in gLiomaS WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation Plants Possess a Cyclic Mitochondrial Metabolic Pathway similar to the Mammalian Metabolic Repair Mechanism Involving Malate Dehydrogenase and l-2-Hydroxyglutarate Dehydrogenase Metabolite damage and its repair or pre-emption Molecular Markers in Low-Grade Glioma-Toward Tumor Reclassification The role of PHD2 mutations in the pathogenesis of erythrocytosis.Role of mitochondrial dysfunction in cancer progression

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

http://www.wikidata.org/entity/Q27667409

description

2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

@ast

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

@en

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

@nl

type

label

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

@ast

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

@en

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

@nl

prefLabel

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

@ast

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

@en

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

@nl

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

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Esther C Y Woon

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Ian J Clifton

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Ivanhoe K H Leung

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Kar Kheng Yeoh

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Lars Hillringhaus

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Ming Yang

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Robert J Klose

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Timothy D W Claridge

http://www.w3.org/2001/XMLSchema#string

Xuan S Li

http://www.w3.org/2001/XMLSchema#string

P2860

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS)

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor

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463-9

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scholarly article

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1103158

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10.1038/EMBOR.2011.43

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5

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12

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Peter J. Ratcliffe

Christopher J. Schofield

Rasheduzzaman Chowdhury

Eleanor A L Bagg

Michael A McDonough

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2011-05-01T00:00:00Z

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50989676

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21460794

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3090014

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