Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
about
LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressorStructural basis of Wnt recognition by FrizzledThe combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescueGentamicin Binds to the Megalin Receptor as a Competitive Inhibitor Using the Common Ligand Binding Motif of Complement Type Repeats: INSIGHT FROM THE NMR STRUCTURE OF THE 10TH COMPLEMENT TYPE REPEAT DOMAIN ALONE AND IN COMPLEX WITH GENTAMICINStructural basis of agrin-LRP4-MuSK signalingStructural Studies of Wnts and Identification of an LRP6 Binding SiteStructure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complexLRP5 and LRP6 in development and diseaseMutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibitionLocal Dkk1 crosstalk from breeding ornaments impedes regeneration of injured male zebrafish fins.Engineering potent long-acting variants of the Wnt inhibitor DKK2Dickkopf-1 is a key regulator of myeloma bone disease: opportunities and challenges for therapeutic interventionMutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity.Three decades of Wnts: a personal perspective on how a scientific field developed.The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells.Negative feedback regulation of Wnt signaling via N-linked fucosylation in zebrafish.Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling.Nanoparticle-mediated expression of a Wnt pathway inhibitor ameliorates ocular neovascularizationHigh Bone Mass-Causing Mutant LRP5 Receptors Are Resistant to Endogenous Inhibitors In VivoBiological activities of histidine-rich peptides; merging biotechnology and nanomedicine.Identification of Novel Candidate Genes for Early-Onset Colorectal Cancer SusceptibilityChemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease.Rational design of DKK3 structure-based small peptides as antagonists of Wnt signaling pathway and in silico evaluation of their efficiencyFrizzled and LRP5/6 receptors for Wnt/β-catenin signalingThe Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation.A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair.Rare nonconservative LRP6 mutations are associated with metabolic syndrome.Mutant LRP6 Impairs Endothelial Cell Functions Associated with Familial Normolipidemic Coronary Artery DiseaseSFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironmentThe sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6The way Wnt works: components and mechanism.Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) Is a Novel Nutritional Therapeutic Target for Hyperlipidemia, Non-Alcoholic Fatty Liver Disease, and Atherosclerosis.Harnessing low-density lipoprotein receptor protein 6 (LRP6) genetic variation and Wnt signaling for innovative diagnostics in complex diseases.The Dkk3 gene encodes a vital intracellular regulator of cell proliferation.Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake.Wnt signaling in triple-negative breast cancer.Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.Rationale for targeting the Wnt signalling modulator Dickkopf-1 for oncology.Wnt signaling in cardiovascular disease: opportunities and challenges.
P2860
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P2860
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
@ast
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
@en
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
@nl
type
label
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
@ast
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
@en
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
@nl
prefLabel
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
@ast
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
@en
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
@en
P2093
Liguo Wang
Seamus Morrone
Travis Biechele
Zhihong Cheng
P2860
P2888
P304
P3181
P356
10.1038/NSMB.2139
P577
2011-10-09T00:00:00Z
P5875
P6179
1022193558