7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes
about
Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitorCrystal Structure of Pim1 Kinase in Complex with a Pyrido[4,3-D]Pyrimidine Derivative Suggests a Unique Binding ModeDe Novo Fragment Design for Drug Discovery and Chemical BiologyInhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmissionIdentifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinasesFluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor.Effect of single amino acid substitution observed in cancer on Pim-1 kinase thermodynamic stability and structureHalogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery.Novel hinge-binding motifs for Janus kinase 3 inhibitors: a comprehensive structure-activity relationship study on tofacitinib bioisosteres.PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma.Identification of type I and type II inhibitors of c-Yes kinase using in silico and experimental techniques.Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma.Insights from Pim1 structure for anti-cancer drug design.A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells.10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.Chemical and photochemical properties of chloroharmine derivatives in aqueous solutions.Using halogen bonds to address the protein backbone: a systematic evaluation.Synthesis of desaza analogues of annomontine and canthin-4-one alkaloids.
P2860
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P2860
7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
7,8-Dichloro-1-oxo-β-carboline ...... ors with Unusual Binding Modes
@ast
7,8-Dichloro-1-oxo-β-carboline ...... ors with Unusual Binding Modes
@en
7,8-Dichloro-1-oxo-β-carboline ...... ors with Unusual Binding Modes
@nl
type
label
7,8-Dichloro-1-oxo-β-carboline ...... ors with Unusual Binding Modes
@ast
7,8-Dichloro-1-oxo-β-carboline ...... ors with Unusual Binding Modes
@en
7,8-Dichloro-1-oxo-β-carboline ...... ors with Unusual Binding Modes
@nl
prefLabel
7,8-Dichloro-1-oxo-β-carboline ...... ors with Unusual Binding Modes
@ast
7,8-Dichloro-1-oxo-β-carboline ...... ors with Unusual Binding Modes
@en
7,8-Dichloro-1-oxo-β-carboline ...... ors with Unusual Binding Modes
@nl
P2093
P2860
P50
P3181
P356
P1476
7,8-Dichloro-1-oxo-β-carboline ...... ors with Unusual Binding Modes
@en
P2093
Alex N Bullock
Christelle Gasser
Doriano Fabbro
Franz Bracher
Jörg Trappe
Jürg Schwaller
Laurent Brault
P2860
P304
P3181
P356
10.1021/JM201286Z
P407
P577
2012-01-12T00:00:00Z