Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis
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7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding ModesTargeting Pim kinases for cancer treatment: opportunities and challengesPim kinase inhibitors: a survey of the patent literaturePim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cellsCharacterization of HJ-PI01 as a novel Pim-2 inhibitor that induces apoptosis and autophagic cell death in triple-negative human breast cancerDe-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis.Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression.The Pim protein kinases regulate energy metabolism and cell growthMechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia.Computational prediction and experimental validation of a novel synthesized pan-PIM inhibitor PI003 and its apoptosis-inducing mechanisms in cervical cancer.Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma.Combinatorial therapy with tamoxifen and trifluoperazine effectively inhibits malignant peripheral nerve sheath tumor growth by targeting complementary signaling cascades.PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cellsOverexpression of pim-3 and protective role in lipopolysaccharide-stimulated hepatic stellate cellsMicroRNA-33a-mediated downregulation of Pim-3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine.Identification of novel light-induced genes in the suprachiasmatic nucleusIdentification of quinones as novel PIM1 kinase inhibitorsCellular responses to HSV-1 infection are linked to specific types of alterations in the host transcriptome.Pim-3 is a Critical Risk Factor in Development and Prognosis of Prostate Cancer.Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells.Pim protein kinase-3 is regulated by TNF-α and promotes endothelial cell sprouting.Gene expression correlation for cancer diagnosis: a pilot study.Roles of Pim-3, a novel survival kinase, in tumorigenesis.The PIM family of serine/threonine kinases in cancer.MiR-377 inhibits the proliferation of pancreatic cancer by targeting Pim-3.Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks.Epicatechin gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon cancer SW480 cells.Inhibition of oncogenic Pim-3 kinase modulates transformed growth and chemosensitizes pancreatic cancer cells to gemcitabine.A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors.Identification of a phenanthrene derivative as a potent anticancer drug with Pim kinase inhibitory activity.Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor.Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2.Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma.Morphologic and molecular events at the invading edge of colorectal carcinomas.MicroRNA-216b-5p Functions as a Tumor-suppressive RNA by Targeting TPT1 in Pancreatic Cancer Cells.Serine threonine kinase Pim-3 regulates STAT3 pathway to inhibit proliferation of human liver cancers.Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447.Ubenimex suppresses Pim-3 kinase expression by targeting CD13 to reverse MDR in HCC cells.Myoglobin-deficient mice activate a distinct cardiac gene expression program in response to isoproterenol-induced hypertrophy.Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver.
P2860
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P2860
Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Proto-oncogene, Pim-3 with ser ...... prevent Bad-mediated apoptosis
@ast
Proto-oncogene, Pim-3 with ser ...... prevent Bad-mediated apoptosis
@en
Proto-oncogene, Pim-3 with ser ...... prevent Bad-mediated apoptosis
@en-gb
Proto-oncogene, Pim-3 with ser ...... prevent Bad-mediated apoptosis
@nl
type
label
Proto-oncogene, Pim-3 with ser ...... prevent Bad-mediated apoptosis
@ast
Proto-oncogene, Pim-3 with ser ...... prevent Bad-mediated apoptosis
@en
Proto-oncogene, Pim-3 with ser ...... prevent Bad-mediated apoptosis
@en-gb
Proto-oncogene, Pim-3 with ser ...... prevent Bad-mediated apoptosis
@nl
prefLabel
Proto-oncogene, Pim-3 with ser ...... prevent Bad-mediated apoptosis
@ast
Proto-oncogene, Pim-3 with ser ...... prevent Bad-mediated apoptosis
@en
Proto-oncogene, Pim-3 with ser ...... prevent Bad-mediated apoptosis
@en-gb
Proto-oncogene, Pim-3 with ser ...... prevent Bad-mediated apoptosis
@nl
P2093
P2860
P921
P3181
P1433
P1476
Proto-oncogene, Pim-3 with ser ...... prevent Bad-mediated apoptosis
@en
P2093
Boryana Konstantinova Popivanova
Chifumi Fujii
Huachuan Zheng
Kenji Omura
Koichi Tsuneyama
Ying-Yi Li
P2860
P3181
P356
10.1111/J.1349-7006.2007.00390.X
P407
P577
2007-03-01T00:00:00Z