Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA - sprookjes - yvandenbroek - TriplyDB

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

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Hepatitis C virus replication is modulated by the interaction of nonstructural protein NS5B and fatty acid synthase Sofosbuvir, a Significant Paradigm Change in HCV Treatment Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance RNA-Dependent RNA Polymerases of Picornaviruses: From the Structure to Regulatory Mechanisms Using the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model to Understand Viral Polymerase Structure, Function and Dynamics Common and unique features of viral RNA-dependent polymerases Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts Crystal Structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interface Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention Viral replication. Structural basis for RNA replication by the hepatitis C virus polymerase Hepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteins The Structure of the RNA-Dependent RNA Polymerase of a Permutotetravirus Suggests a Link between Primer-Dependent and Primer-Independent Polymerases Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase A Structural Overview of RNA-Dependent RNA Polymerases from the Flaviviridae Family Perturbation in the conserved methyltransferase-polymerase interface of flavivirus NS5 differentially affects polymerase initiation and elongation Dynamics of hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B in complex with RNA Efficiency of incorporation and chain termination determines the inhibition potency of 2'-modified nucleotide analogs against hepatitis C virus polymerase Mechanism of inhibition for BMS-791325, a novel non-nucleoside inhibitor of hepatitis C virus NS5B polymerase.Cross-genotypic examination of hepatitis C virus polymerase inhibitors reveals a novel mechanism of action for thumb binders Structure-function relationships underlying the replication fidelity of viral RNA-dependent RNA polymerases.Identification, molecular cloning, and analysis of full-length hepatitis C virus transmitted/founder genotypes 1, 3, and 4 Identification of dengue viral RNA-dependent RNA polymerase inhibitor using computational fragment-based approaches and molecular dynamics study.NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase.Genetic recombination in plant-infecting messenger-sense RNA viruses: overview and research perspectives.Inhibition of hepatitis C viral RNA-dependent RNA polymerase by α-P-boranophosphate nucleotides: exploring a potential strategy for mechanism-based HCV drug design Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase Allosterically Block the Transition from Initiation to Elongation Hydrogen/Deuterium Exchange Kinetics Demonstrate Long Range Allosteric Effects of Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase.The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection.Viruses and viral proteins.Epigenetic Pathways of Oncogenic Viruses: Therapeutic Promises.The juxtamembrane sequence of the Hepatitis C virus polymerase can affect RNA synthesis and inhibition by allosteric polymerase inhibitors.Polymerases of paramyxoviruses and pneumoviruses.Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.Picornaviral polymerase structure, function, and fidelity modulation.The role of the priming loop in influenza A virus RNA synthesis.A Complex Network of Interactions between S282 and G283 of Hepatitis C Virus Nonstructural Protein 5B and the Template Strand Affects Susceptibility to Sofosbuvir and Ribavirin.NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B.Identification of a Conserved RNA-dependent RNA Polymerase (RdRp)-RNA Interface Required for Flaviviral Replication.Molecular simulations to delineate functional conformational transitions in the HCV polymerase.

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P2860

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

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description

2012 nî lūn-bûn

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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2012 թվականի հունիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

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Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

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Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

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Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

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Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

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Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

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Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

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Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

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Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

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Journal of Virology

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Structure of hepatitis C virus polymerase in complex with primer-template RNA

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P2093

Angela M Lam

http://www.w3.org/2001/XMLSchema#string

Eisuke Murakami

http://www.w3.org/2001/XMLSchema#string

Jinfa Du

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Michael J Otto

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Michael J Sofia

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Philip A Furman

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Ralph T Mosley

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Rena L Grice

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P2860

MolProbity: all-atom structure validation for macromolecular crystallography

De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus

Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues

Mechanism of Activation of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus.

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1758027

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10.1128/JVI.00386-12

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12

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86

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Thomas E Edwards

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2012-04-11T00:00:00Z

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22496223

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3393583

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