Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
about
Hepatitis C virus replication is modulated by the interaction of nonstructural protein NS5B and fatty acid synthaseSofosbuvir, a Significant Paradigm Change in HCV TreatmentInhibitors of the Hepatitis C Virus Polymerase; Mode of Action and ResistanceRNA-Dependent RNA Polymerases of Picornaviruses: From the Structure to Regulatory MechanismsUsing the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model to Understand Viral Polymerase Structure, Function and DynamicsCommon and unique features of viral RNA-dependent polymerasesConformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an InhibitorStructures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contactsCrystal Structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interfaceInhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral interventionViral replication. Structural basis for RNA replication by the hepatitis C virus polymeraseHepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteinsThe Structure of the RNA-Dependent RNA Polymerase of a Permutotetravirus Suggests a Link between Primer-Dependent and Primer-Independent PolymerasesBiochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA PolymeraseA Structural Overview of RNA-Dependent RNA Polymerases from the Flaviviridae FamilyPerturbation in the conserved methyltransferase-polymerase interface of flavivirus NS5 differentially affects polymerase initiation and elongationDynamics of hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B in complex with RNAEfficiency of incorporation and chain termination determines the inhibition potency of 2'-modified nucleotide analogs against hepatitis C virus polymeraseMechanism of inhibition for BMS-791325, a novel non-nucleoside inhibitor of hepatitis C virus NS5B polymerase.Cross-genotypic examination of hepatitis C virus polymerase inhibitors reveals a novel mechanism of action for thumb bindersStructure-function relationships underlying the replication fidelity of viral RNA-dependent RNA polymerases.Identification, molecular cloning, and analysis of full-length hepatitis C virus transmitted/founder genotypes 1, 3, and 4Identification of dengue viral RNA-dependent RNA polymerase inhibitor using computational fragment-based approaches and molecular dynamics study.NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase.Genetic recombination in plant-infecting messenger-sense RNA viruses: overview and research perspectives.Inhibition of hepatitis C viral RNA-dependent RNA polymerase by α-P-boranophosphate nucleotides: exploring a potential strategy for mechanism-based HCV drug designThumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase Allosterically Block the Transition from Initiation to ElongationHydrogen/Deuterium Exchange Kinetics Demonstrate Long Range Allosteric Effects of Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase.The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection.Viruses and viral proteins.Epigenetic Pathways of Oncogenic Viruses: Therapeutic Promises.The juxtamembrane sequence of the Hepatitis C virus polymerase can affect RNA synthesis and inhibition by allosteric polymerase inhibitors.Polymerases of paramyxoviruses and pneumoviruses.Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.Picornaviral polymerase structure, function, and fidelity modulation.The role of the priming loop in influenza A virus RNA synthesis.A Complex Network of Interactions between S282 and G283 of Hepatitis C Virus Nonstructural Protein 5B and the Template Strand Affects Susceptibility to Sofosbuvir and Ribavirin.NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B.Identification of a Conserved RNA-dependent RNA Polymerase (RdRp)-RNA Interface Required for Flaviviral Replication.Molecular simulations to delineate functional conformational transitions in the HCV polymerase.
P2860
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P2860
Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
@ast
Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
@en
Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
@nl
type
label
Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
@ast
Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
@en
Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
@nl
prefLabel
Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
@ast
Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
@en
Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
@nl
P2093
P2860
P3181
P356
P1433
P1476
Structure of hepatitis C virus polymerase in complex with primer-template RNA
@en
P2093
Angela M Lam
Eisuke Murakami
Michael J Otto
Michael J Sofia
Philip A Furman
Ralph T Mosley
Rena L Grice
P2860
P304
P3181
P356
10.1128/JVI.00386-12
P577
2012-04-11T00:00:00Z