Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase
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The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5AHepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5AFurther Insights into the Roles of GTP and the C Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA SynthesisA Comprehensive Structure-Function Comparison of Hepatitis C Virus Strain JFH1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture across GenotypesStructure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNATwo Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405Viral replication. Structural basis for RNA replication by the hepatitis C virus polymeraseA cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5AC-Terminal Auto-Regulatory Motif of Hepatitis C Virus NS5B Interacts with Human VAPB-MSP to Form a Dynamic Replication ComplexInitiation of RNA synthesis by the hepatitis C virus RNA-dependent RNA polymerase is affected by the structure of the RNA template.RNA polymerase activity and specific RNA structure are required for efficient HCV replication in cultured cells.Regulation of de novo-initiated RNA synthesis in hepatitis C virus RNA-dependent RNA polymerase by intermolecular interactions.A weak neutralizing antibody response to hepatitis C virus envelope glycoprotein enhances virus infectionViral double-strand RNA-binding proteins can enhance innate immune signaling by toll-like Receptor 3.Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner.The hepatitis C virus core protein can modulate RNA-dependent RNA synthesis by the 2a polymerase.Interferon and ribavirin combination treatment synergistically inhibit HCV internal ribosome entry site mediated translation at the level of polyribosome formation.Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains.Hepatitis C virus nonstructural protein 5B is involved in virus morphogenesis.Advances and challenges in studying hepatitis C virus in its native environment.The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection.Norovirus RNA-dependent RNA polymerase is phosphorylated by an important survival kinase, AktHepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA.Mapping of functional domains of the lipid kinase phosphatidylinositol 4-kinase type III alpha involved in enzymatic activity and hepatitis C virus replication.Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B.Molecular and structural basis for the roles of hepatitis C virus polymerase NS5B amino acids 15, 223, and 321 in viral replication and drug resistance.Structural biology. Kickstarting a viral RNA polymerase.Construction of a chimeric hepatitis C virus replicon based on a strain isolated from a chronic hepatitis C patient.Hepatitis C virus NS5B polymerase primes innate immune signaling.The conserved lysine 151 of HCV NS5B modulates viral genome replication and infectious virus production.Hepatitis C virus-induced prion protein expression facilitates hepatitis C virus replication.Liver transplantation for fulminant genotype 2a/c hepatitis C virus marked by a rapid recurrence followed by cure.Survey of the 2009 commercial optical biosensor literature.
P2860
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P2860
Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase
@ast
Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase
@en
Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase
@nl
type
label
Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase
@ast
Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase
@en
Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase
@nl
prefLabel
Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase
@ast
Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase
@en
Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase
@nl
P2093
P2860
P50
P356
P1433
P1476
Structural and functional analysis of hepatitis C virus strain JFH1 polymerase
@en
P2093
Matthis Geitmann
Melanie Schmitt
Philip Simister
Rahel Klein
P2860
P304
11926-11939
P356
10.1128/JVI.01008-09
P577
2009-09-09T00:00:00Z