Evolutionary history and metabolic insights of ancient mammalian uricases
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Uric acid in metabolic syndrome: From an innocent bystander to a central playerAn experimental phylogeny to benchmark ancestral sequence reconstructionPhyloBot: A Web Portal for Automated Phylogenetics, Ancestral Sequence Reconstruction, and Exploration of Mutational TrajectoriesCatalysis and Structure of Zebrafish Urate Oxidase Provide Insights into the Origin of Hyperuricemia in HominoidsRapid bursts and slow declines: on the possible evolutionary trajectories of enzymesSite-specific albumination of a therapeutic protein with multi-subunit to prolong activity in vivoUric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominidsMutational studies on resurrected ancestral proteins reveal conservation of site-specific amino acid preferences throughout evolutionary history.New insights on the risk for cardiovascular disease in African Americans: the role of added sugars.The peroxisomal protein import machinery displays a preference for monomeric substrates.Functional Divergence of the Nuclear Receptor NR2C1 as a Modulator of Pluripotentiality During Hominid Evolution.Metabolic and Kidney Diseases in the Setting of Climate Change, Water Shortage, and Survival FactorsResurrecting ancestral structural dynamics of an antiviral immune receptor: adaptive binding pocket reorganization repeatedly shifts RNA preference.Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1AEGF Receptor Inhibition Alleviates Hyperuricemic Nephropathy.A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development PropertiesPerspective: A Historical and Scientific Perspective of Sugar and Its Relation with Obesity and Diabetes.Development of Therapeutic Chimeric Uricase by Exon Replacement/Restoration and Site-Directed MutagenesisAnalysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling.Hyperuricemia-Related Diseases and Xanthine Oxidoreductase (XOR) Inhibitors: An Overview.Retrocyclins neutralize bacterial toxins by potentiating their unfolding.Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstructionAncient insights into uric acid metabolism in primates.Pacific Populations, Metabolic Disease and 'Just-So Stories': A Critique of the 'Thrifty Genotype' Hypothesis in Oceania.Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.Soluble Uric Acid Activates the NLRP3 Inflammasome.C-peptide antioxidant adaptive pathways in β cells and diabetes.Physiological functions and pathogenic potential of uric acid: A review.A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice.The identification of an integral membrane, cytochrome c urate oxidase completes the catalytic repertoire of a therapeutic enzyme[Hyperuricemia and gout : New aspects of an old disease].Uric acid in plants and microorganisms: Biological applications and genetics - A review.Mechanism of high affinity inhibition of the human urate transporter URAT1Coevolution of URAT1 and Uricase during Primate Evolution: Implications for Serum Urate Homeostasis and Gout.Febuxostat Attenuates Renal Damage besides Exerting Hypouricemic Effect in Streptozotocin-Induced Diabetic Rats.Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout.Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway.The sedentary (r)evolution: Have we lost our metabolic flexibility?Designing a mutant Candida uricase with improved polymerization state and enzymatic activity.Mechanochemical evolution of the giant muscle protein titin as inferred from resurrected proteins.
P2860
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P2860
Evolutionary history and metabolic insights of ancient mammalian uricases
description
2014 nî lūn-bûn
@nan
2014 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մարտին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Evolutionary history and metabolic insights of ancient mammalian uricases
@ast
Evolutionary history and metabolic insights of ancient mammalian uricases
@en
Evolutionary history and metabolic insights of ancient mammalian uricases
@nl
type
label
Evolutionary history and metabolic insights of ancient mammalian uricases
@ast
Evolutionary history and metabolic insights of ancient mammalian uricases
@en
Evolutionary history and metabolic insights of ancient mammalian uricases
@nl
prefLabel
Evolutionary history and metabolic insights of ancient mammalian uricases
@ast
Evolutionary history and metabolic insights of ancient mammalian uricases
@en
Evolutionary history and metabolic insights of ancient mammalian uricases
@nl
P2093
P2860
P3181
P356
P1476
Evolutionary history and metabolic insights of ancient mammalian uricases
@en
P2093
Christina Cicerchi
Christina L Graves
Eric A Gaucher
James T Kratzer
Michael N Murphy
Miguel A Lanaspa
Peter A Tipton
Richard J Johnson
P2860
P304
P3181
P356
10.1073/PNAS.1320393111
P407
P577
2014-03-11T00:00:00Z