about
Evolution of minimal specificity and promiscuity in steroid hormone receptorsProtein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestorModulation of human nuclear receptor LRH-1 activity by phospholipids and SHPCrystal structure of a covalent intermediate of endogenous human arylsulfatase ACrystal structure of an ancient protein: evolution by conformational epistasisPhospholipid--driven gene regulationThe structure, function and evolution of proteins that bind DNA and RNACrystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding siteFunctional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamilyAn epistatic ratchet constrains the direction of glucocorticoid receptor evolutionResurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolutionDivergent Sequence Tunes Ligand Sensitivity in Phospholipid-regulated Hormone ReceptorsX-Ray Crystal Structure of the Ancestral 3-Ketosteroid Receptor–Progesterone–Mifepristone Complex Shows Mifepristone Bound at the Coactivator Binding InterfaceA phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesisVestigialization of an Allosteric Switch: Genetic and Structural Mechanisms for the Evolution of Constitutive Activity in a Steroid Hormone ReceptorEvolutionary history and metabolic insights of ancient mammalian uricasesStructural Basis for Ligand Regulation of the Fatty Acid-binding Protein 5, Peroxisome Proliferator-activated Receptor / (FABP5-PPAR / ) Signaling PathwayCrystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists Reveal a Novel Mechanism of ActivationCrystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA.Identification of a small molecular insulin receptor agonist with potent antidiabetes activity.Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.Crystallization and preliminary X-ray diffraction analysis of Sfh3, a member of the Sec14 protein superfamily.Integration of G protein α (Gα) signaling by the regulator of G protein signaling 14 (RGS14).Evolution of DNA specificity in a transcription factor family produced a new gene regulatory moduleIdentification of a lipid scrambling domain in ANO6/TMEM16F.Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.Estrogen receptor α polymorphism in a species with alternative behavioral phenotypesStructure of glycerol dehydrogenase from Serratia.Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes.Structure and Dynamics of the Liver Receptor Homolog 1-PGC1α Complex.Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner.Glucocorticoid receptor control of transcription: precision and plasticity via allostery.A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1).Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus.Nucleotide Binding to ARL2 in the TBCD∙ARL2∙β-Tubulin Complex Drives Conformational Changes in β-Tubulin.Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements.The nuclear receptor superfamily: A structural perspectiveThe Effect of Anticoagulants, Temperature, and Time on the Human Plasma Metabolome and Lipidome from Healthy Donors as Determined by Liquid Chromatography-Mass Spectrometry.
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description
onderzoeker
@nl
researcher
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հետազոտող
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name
Eric A. Ortlund
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Eric A. Ortlund
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Eric A. Ortlund
@es
Eric A. Ortlund
@nl
Eric A. Ortlund
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type
label
Eric A. Ortlund
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Eric A. Ortlund
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Eric A. Ortlund
@es
Eric A. Ortlund
@nl
Eric A. Ortlund
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prefLabel
Eric A. Ortlund
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Eric A. Ortlund
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Eric A. Ortlund
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Eric A. Ortlund
@nl
Eric A. Ortlund
@sl
P106
P1153
6507471949
P31
P496
0000-0001-8855-3029