Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response
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The Roles of RNase-L in Antimicrobial Immunity and the Cytoskeleton-Associated Innate ResponseCrystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activationIn Vivo Cleavage Map Illuminates the Central Role of RNase E in Coding and Non-coding RNA PathwaysPseudokinases: update on their functions and evaluation as new drug targets.Molecular mechanisms of human IRE1 activation through dimerization and ligand bindingRNase L targets distinct sites in influenza A virus RNAs.Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-bindingFortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death.Genome-wide mRNA processing in methanogenic archaea reveals post-transcriptional regulation of ribosomal protein synthesis.RNase L interacts with Filamin A to regulate actin dynamics and barrier function for viral entryRNase L attenuates mitogen-stimulated gene expression via transcriptional and post-transcriptional mechanisms to limit the proliferative responseFunctionally conserved architecture of hepatitis C virus RNA genomes.Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3Structural biology of innate immunity.OASes and STING: adaptive evolution in concertHuman RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome.Structural Basis for the Non-catalytic Functions of Protein Kinases.The CRISPR-associated Csx1 protein of Pyrococcus furiosus is an adenosine-specific endoribonuclease.Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6RNase L Suppresses Androgen Receptor Signaling, Cell Migration and Matrix Metalloproteinase Activity in Prostate Cancer Cells.Can't RIDD off viruses.OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids.METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.Emerging roles for RNA degradation in viral replication and antiviral defense.Rapid RNase L-Driven Arrest of Protein Synthesis in the dsRNA Response without Degradation of Translation Machinery.Nucleotide-binding mechanisms in pseudokinases.Evolutionary adaptation revealed by comparative genome analysis of woolly mammoths and elephants.Sequence-Specific Sensing of Nucleic Acids.The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.Curcumin, a natural antioxidant, acts as a noncompetitive inhibitor of human RNase L in presence of its cofactor 2-5A in vitro.Grc3 programs the essential endoribonuclease Las1 for specific RNA cleavage.Nuclease integrated kinase super assemblies (NiKs) and their role in RNA processing.A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L.Molecular Mechanisms for the Adaptive Switching Between the OAS/RNase L and OASL/RIG-I Pathways in Birds and Mammals.RNASEL binds 2'-5' oligoadenylate
P2860
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P2860
Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response
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2014 nî lūn-bûn
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2014 թուականի Մարտին հրատարակուած գիտական յօդուած
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2014 թվականի մարտին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response
@ast
Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response
@en
Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response
@nl
type
label
Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response
@ast
Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response
@en
Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response
@nl
prefLabel
Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response
@ast
Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response
@en
Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response
@nl
P2093
P2860
P356
P1433
P1476
Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response
@en
P2093
Alexei Korennykh
Alisha Chitrakar
Gena Whitney
Jesse Donovan
Yuchen Han
P2860
P304
P356
10.1126/SCIENCE.1249845
P407
P50
P577
2014-02-27T00:00:00Z