GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.
about
Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1Metabolomics applied to the pancreatic isletPotential roles of GPR120 and its agonists in the management of diabetesInterplay between lipids and branched-chain amino acids in development of insulin resistanceChronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cellsThe action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db miceAMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodentsVariants in the FFAR1 gene are associated with beta cell function.Palmitate-induced beta-cell dysfunction is associated with excessive NO production and is reversed by thiazolidinedione-mediated inhibition of GPR40 transduction mechanisms.Glucolipotoxicity of the pancreatic beta cell.Increased glucose metabolism and glycerolipid formation by fatty acids and GPR40 receptor signaling underlies the fatty acid potentiation of insulin secretionIdentification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity.Lipid receptors and islet function: therapeutic implications?Alteration of the glucagon axis in GPR120 (FFAR4) knockout mice: a role for GPR120 in glucagon secretion.Beta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass.Adipose differentiation-related protein regulates lipids and insulin in pancreatic isletsA potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents.PPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cellsDefective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice.Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity.GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivoPerilipin 5 regulates islet lipid metabolism and insulin secretion in a cAMP-dependent manner: implication of its role in the postprandial insulin secretion.The intestinal microbiome and skeletal fitness: Connecting bugs and bonesEmerging roles for protein histidine phosphorylation in cellular signal transduction: lessons from the islet beta-cell.G protein-coupled receptors and insulin secretion: 119 and countingPancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational AnalysisGPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism.Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases.PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acidsIdentification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptorThe G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin.The free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation.Gustducin couples fatty acid receptors to GLP-1 release in colon.Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects.Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in miceThe fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.Glucolipotoxicity: fuel excess and beta-cell dysfunction.
P2860
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P2860
GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
GPR40 is necessary but not suf ...... of insulin secretion in vivo.
@ast
GPR40 is necessary but not suf ...... of insulin secretion in vivo.
@en
GPR40 is necessary but not suf ...... of insulin secretion in vivo.
@nl
type
label
GPR40 is necessary but not suf ...... of insulin secretion in vivo.
@ast
GPR40 is necessary but not suf ...... of insulin secretion in vivo.
@en
GPR40 is necessary but not suf ...... of insulin secretion in vivo.
@nl
altLabel
GPR40 is necessary but not suf ...... n of insulin secretion in vivo
@en
prefLabel
GPR40 is necessary but not suf ...... of insulin secretion in vivo.
@ast
GPR40 is necessary but not suf ...... of insulin secretion in vivo.
@en
GPR40 is necessary but not suf ...... of insulin secretion in vivo.
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
GPR40 is necessary but not suf ...... n of insulin secretion in vivo
@en
P2093
Caroline Tremblay
Daniel C-H Lin
Elizabeth Oseid
Martin G Latour
Thomas L Jetton
P2860
P304
P3181
P356
10.2337/DB06-1532
P407
P577
2007-04-01T00:00:00Z