Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation. - sprookjes - yvandenbroek - TriplyDB

Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation.

Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation.

http://www.wikidata.org/entity/Q27935765

about

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD Meckel-Gruber syndrome protein MKS3 is required for endoplasmic reticulum-associated degradation of surfactant protein C The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER Inhibition of p97-dependent protein degradation by Eeyarestatin I Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step One step at a time: endoplasmic reticulum-associated degradation Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3 Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin Recent technical developments in the study of ER-associated degradation Endoplasmic reticulum-mediated protein quality control in Arabidopsis Key steps in ERAD of luminal ER proteins reconstituted with purified components Endoplasmic Reticulum-associated Degradation of Pca1p, a Polytopic Protein, via Interaction with the Proteasome at the Membrane The budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7).A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p A proteasomal ATPase contributes to dislocation of endoplasmic reticulum-associated degradation (ERAD) substrates.Sel1p/Ubx2p participates in a distinct Cdc48p-dependent endoplasmic reticulum-associated degradation pathway.Yos9p assists in the degradation of certain nonglycosylated proteins from the endoplasmic reticulum Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization.Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery.Cdc48/p97 mediates UV-dependent turnover of RNA Pol II.Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway UBXD Proteins: A Family of Proteins with Diverse Functions in Cancer The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system The role of a novel p97/valosin-containing protein-interacting motif of gp78 in endoplasmic reticulum-associated degradation Control of p97 function by cofactor binding Cytosolic entry of Shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways Small but versatile: the extraordinary functional and structural diversity of the beta-grasp fold The role of the UPS in cystic fibrosis.Reconstructing the ubiquitin network: cross-talk with other systems and identification of novel functions Modularity of the Hrd1 ERAD complex underlies its diverse client range.A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice.

P2860

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P2860

Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation.

http://www.wikidata.org/entity/Q27935765

description

2005 nî lūn-bûn

@nan

2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

Membrane-bound Ubx2 recruits C ...... ssociated protein degradation.

@ast

Membrane-bound Ubx2 recruits C ...... ssociated protein degradation.

@en

Membrane-bound Ubx2 recruits C ...... ssociated protein degradation.

@nl

type

label

Membrane-bound Ubx2 recruits C ...... ssociated protein degradation.

@ast

Membrane-bound Ubx2 recruits C ...... ssociated protein degradation.

@en

Membrane-bound Ubx2 recruits C ...... ssociated protein degradation.

@nl

prefLabel

Membrane-bound Ubx2 recruits C ...... ssociated protein degradation.

@ast

Membrane-bound Ubx2 recruits C ...... ssociated protein degradation.

@en

Membrane-bound Ubx2 recruits C ...... ssociated protein degradation.

@nl

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P1433

Nature Cell Biology

P1476

Membrane-bound Ubx2 recruits C ...... ssociated protein degradation.

@en

P2093

Alexander Buchberger

http://www.w3.org/2001/XMLSchema#string

Christian Schuberth

http://www.w3.org/2001/XMLSchema#string

P2860

A membrane protein required for dislocation of misfolded proteins from the ER

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways

A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation

Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments

The UBX domain: a widespread ubiquitin-like module

Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone.

Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation

P2888

P304

999-1006

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P31

scholarly article

P3181

1891536

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P356

10.1038/NCB1299

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P433

10

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P478

7

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P577

2005-10-01T00:00:00Z

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P6179

1040894578

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P698

16179952

http://www.w3.org/2001/XMLSchema#string

P921

VCP-NPL4-UFD1 AAA ATPase complex