Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties
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PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinPro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pHTrafficking regulation of proteins in Alzheimer's diseaseEndosomal proteolysis of internalized insulin at the C-terminal region of the B chain by cathepsin DSpotlight on BACE: the secretases as targets for treatment in Alzheimer diseaseAlzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful agingThe normal and pathologic roles of the Alzheimer's β-secretase, BACE1Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway.Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines.Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology.Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases.A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein.Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Inhibition of BACE1 for therapeutic use in Alzheimer's disease.Regulation of APP cleavage by alpha-, beta- and gamma-secretases.Beta-secretase: structure, function, and evolution.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseEnzymic properties of recombinant BACE2.Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.Beta-secretase as a target for the treatment of Alzheimer's disease.Pharmacogenomics for the treatment of dementia.The effect of HIV protease inhibitors on amyloid-β peptide degradation and synthesis in human cells and Alzheimer's disease animal modelBACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic miceAlzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme.Membrane proteases in the bacterial protein secretion and quality control pathway.The Alzheimer's disease beta-secretase enzyme, BACE1.Activation of protein kinase C modulates BACE1-mediated beta-secretase activity.Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.β-Secretase: its biology as a therapeutic target in diseasesStructure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's diseaseThe Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease.Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) as a biological candidate marker of Alzheimer's disease.The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiologyCell biology, regulation and inhibition of beta-secretase (BACE-1).Mechanism-based treatments for Alzheimer's disease.The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential.
P2860
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P2860
Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties
description
2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2000
@ast
im Juli 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/07/14)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/07/14)
@nl
наукова стаття, опублікована в липні 2000
@uk
name
Characterization of Alzheimer' ...... member with unusual properties
@ast
Characterization of Alzheimer' ...... member with unusual properties
@en
Characterization of Alzheimer' ...... member with unusual properties
@nl
type
label
Characterization of Alzheimer' ...... member with unusual properties
@ast
Characterization of Alzheimer' ...... member with unusual properties
@en
Characterization of Alzheimer' ...... member with unusual properties
@nl
prefLabel
Characterization of Alzheimer' ...... member with unusual properties
@ast
Characterization of Alzheimer' ...... member with unusual properties
@en
Characterization of Alzheimer' ...... member with unusual properties
@nl
P2093
P356
P1476
Characterization of Alzheimer' ...... member with unusual properties
@en
P2093
B. D. Bennett
E. A. Mendiaz
P304
21099–21106
P356
10.1074/JBC.M002095200
P407
P577
2000-07-14T00:00:00Z