Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart
about
Angiotensin II-forming heart chymase is a mast-cell-specific enzymeCellular localization and regional distribution of an angiotensin II-forming chymase in the heartActive monomers of human beta-tryptase have expanded substrate specificitiesMast Cell: A Multi-Functional Master CellThe Role of Mast Cell Specific Chymases and Tryptases in Tumor AngiogenesisAn evolving story of angiotensin-II-forming pathways in rodents and humansHuman heart as a shock organ in anaphylaxisMast cell proteoglycansCrystal structure of a complex of human chymase with its benzimidazole derived inhibitorChymase cleavage of stem cell factor yields a bioactive, soluble productA novel vascular smooth muscle chymase is upregulated in hypertensive ratsRat mast cell protease-I enhances immunoglobulin E production by mouse B cells stimulated with interleukin-4Novel Cardiac Intracrine Mechanisms Based on Ang-(1-12)/Chymase Axis Require a Revision of Therapeutic Approaches in Human Heart Disease.Direct evidence for intrarenal chymase-dependent angiotensin II formation on the diabetic renal microvasculature.Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidasesMajor role for ACE-independent intrarenal ANG II formation in type II diabetes.Association of the common genetic polymorphisms and haplotypes of the chymase gene with left ventricular mass in male patients with symptomatic aortic stenosis.Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodentsChymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue.Angiotensin I-converting enzyme: genotype and disease associations.Effects of angiotensin II generated by an angiotensin converting enzyme-independent pathway on left ventricular performance in the conscious baboonIncreased angiotensin-I converting enzyme gene expression in the failing human heart. Quantification by competitive RNA polymerase chain reaction.Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis.Advanced glycation end products activate a chymase-dependent angiotensin II-generating pathway in diabetic complications.Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1.Elevated plasma chymotrypsin-like protease (chymase) activity in women with preeclampsia.Placenta-derived chymotrypsin-like protease (CLP) disturbs endothelial junctional structure in preeclampsiaEstrogen inhibits mast cell chymase release to prevent pressure overload-induced adverse cardiac remodelingChymase inhibition prevents fibronectin and myofibrillar loss and improves cardiomyocyte function and LV torsion angle in dogs with isolated mitral regurgitation.Aliskiren: An orally active renin inhibitor.Hydrolysis of angiotensin peptides by human angiotensin I-converting enzyme and the resensitization of B2 kinin receptorsAngiotensin II receptor blockers improve peripheral endothelial function: a meta-analysis of randomized controlled trials.Involvement of chymase-mediated angiotensin II generation in blood pressure regulation.Beta adrenergic blockers lower renin in patients treated with ACE inhibitors and diureticsDeranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sl(d) miceMast cells are required for the development of renal fibrosis in the rodent unilateral ureteral obstruction model.Human mast cells (HMC-1 5C6) enhance interleukin-6 production by quiescent and lipopolysaccharide-stimulated human coronary artery endothelial cells.Angiotensin II formation in the intact human heart. Predominance of the angiotensin-converting enzyme pathwayConditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice.Impact of Mast Cell Chymase on Renal Disease Progression.
P2860
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P2860
Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart
description
1990 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1990
@ast
im Dezember 1990 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1990/12/25)
@sk
vědecký článek publikovaný v roce 1990
@cs
wetenschappelijk artikel (gepubliceerd op 1990/12/25)
@nl
наукова стаття, опублікована в грудні 1990
@uk
name
Identification of a highly spe ...... ming enzyme in the human heart
@ast
Identification of a highly spe ...... ming enzyme in the human heart
@en
Identification of a highly spe ...... ming enzyme in the human heart
@nl
type
label
Identification of a highly spe ...... ming enzyme in the human heart
@ast
Identification of a highly spe ...... ming enzyme in the human heart
@en
Identification of a highly spe ...... ming enzyme in the human heart
@nl
prefLabel
Identification of a highly spe ...... ming enzyme in the human heart
@ast
Identification of a highly spe ...... ming enzyme in the human heart
@en
Identification of a highly spe ...... ming enzyme in the human heart
@nl
P2093
P3181
P1476
Identification of a highly spe ...... ming enzyme in the human heart
@en
P2093
P304
22348-22357
P3181
P407
P577
1990-12-01T00:00:00Z