A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
about
MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genesSKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC functionPresenilin 2 interacts with sorcin, a modulator of the ryanodine receptorPresenilin 1 is linked with gamma-secretase activity in the detergent solubilized stateThe gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleusIntegrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain.PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinA presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genesRegulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2bThe adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathwayTspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammalsPresenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and NotchThe translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activationThe prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancerEpstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchICSHARP is a novel component of the Notch/RBP-Jkappa signalling pathway.Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in DrosophilaIsolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary glandSEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradationBinding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2Hydrocephalus and abnormal subcommissural organ in mice lacking presenilin-1 in Wnt1 cell lineagesThe ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patientsSequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growthDirect inhibition of the NOTCH transcription factor complexScratching the surface of skin developmentSuppressor role of activating transcription factor 2 (ATF2) in skin cancerSignaling effect of amyloid-beta(42) on the processing of AbetaPPThe Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretaseIdentification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1A novel mechanism for the regulation of amyloid precursor protein metabolismThe transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell developmentInactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunctionConditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegenerationAlzheimer's Disease and Hippocampal Adult Neurogenesis; Exploring Shared MechanismsMolecular Mechanisms in the Pathogenesis of Alzheimer's disease and Tauopathies-Prion-Like Seeded Aggregation and Phosphorylation
P2860
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P2860
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
A presenilin-1-dependent gamma ...... of Notch intracellular domain
@ast
A presenilin-1-dependent gamma ...... of Notch intracellular domain
@en
A presenilin-1-dependent gamma ...... of Notch intracellular domain
@nl
type
label
A presenilin-1-dependent gamma ...... of Notch intracellular domain
@ast
A presenilin-1-dependent gamma ...... of Notch intracellular domain
@en
A presenilin-1-dependent gamma ...... of Notch intracellular domain
@nl
altLabel
A presenilin-1-dependent γ-sec ...... of Notch intracellular domain
@en
prefLabel
A presenilin-1-dependent gamma ...... of Notch intracellular domain
@ast
A presenilin-1-dependent gamma ...... of Notch intracellular domain
@en
A presenilin-1-dependent gamma ...... of Notch intracellular domain
@nl
P2093
P3181
P356
P1433
P1476
A presenilin-1-dependent gamma ...... of Notch intracellular domain
@en
P2093
B De Strooper
E H Schroeter
K Craessaerts
V Schrijvers
P2888
P304
P3181
P356
10.1038/19083
P407
P577
1999-04-08T00:00:00Z
P5875
P6179
1048748829