The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase
about
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cellsMT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell developmentDelta activity independent of its activity as a ligand of NotchProtease regulation: the Yin and Yang of neural development and diseaseFrom fly wings to targeted cancer therapies: a centennial for notch signalingMAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surfaceGDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECKThe divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligandsThe extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surfaceThe intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activityThe canonical Notch signaling pathway: unfolding the activation mechanism.The Notch pathway in the annelid Platynereis: insights into chaetogenesis and neurogenesis processes.Characterisation of endothelin converting enzyme-1 shedding from endothelial cells.A novel function of DELTA-NOTCH signalling mediates the transition from proliferation to neurogenesis in neural progenitor cellsMeltrin beta/ADAM19 interacting with EphA4 in developing neural cells participates in formation of the neuromuscular junction.A miniaturized 1536-well format gamma-secretase assayActive-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10Tissue inhibitor of metalloproteinase-3 (TIMP-3) regulates hematopoiesis and bone formation in vivo.ADAM-17: the enzyme that does it all.Notch and delta mRNAs in early-stage and mid-stage drosophila embryos exhibit complementary patterns of protein-producing potentialsNeuralized promotes basal to apical transcytosis of delta in epithelial cellsEctodomain shedding of interleukin-2 receptor beta and generation of an intracellular functional fragmentRETRACTED: Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serumNotch inhibitors for cancer treatment.No evidence for a functional role of bi-directional Notch signaling during angiogenesis.Cancer stem cells maintain a hierarchy of differentiation by creating their nicheThe Notch ligand Delta-like 1 integrates inputs from TGFbeta/Activin and Wnt pathways.A glycosphingolipid binding domain controls trafficking and activity of the mammalian notch ligand delta-like 1Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.Differential surface expression of ADAM10 and ADAM17 on human T lymphocytes and tumor cells.Normal development in mice over-expressing the intracellular domain of DLL1 argues against reverse signaling by DLL1 in vivo.Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase.Targeting paediatric acute lymphoblastic leukaemia: novel therapies currently in developmentJagged1 intracellular domain-mediated inhibition of Notch1 signalling regulates cardiac homeostasis in the postnatal heart.The role of notch in modeling and maintaining the vasculature.Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation.Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease.Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk.GPI-AP release in cellular, developmental, and reproductive biology.Substrate specificity of gamma-secretase and other intramembrane proteases.
P2860
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P2860
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase
@ast
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase
@en
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase
@nl
type
label
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase
@ast
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase
@en
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase
@nl
prefLabel
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase
@ast
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase
@en
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase
@nl
P2093
P2860
P921
P3181
P356
P1476
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase
@en
P2093
Alain Israel
Christel Brou
Delphine Ndiaye
Frederique Logeat
Yacine Laabi
P2860
P304
P3181
P356
10.1073/PNAS.1230693100
P407
P577
2003-06-24T00:00:00Z