Presenilin is required for activity and nuclear access of Notch in Drosophila
about
A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 proteinSKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC functionPresenilin 2 interacts with sorcin, a modulator of the ryanodine receptorIdentification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulationThe gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleusIntegrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain.RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genesSegmental expression of Notch and Hairy genes in nephrogenesisMutations in NOTCH1 cause aortic valve diseaseThe transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2bEpstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchICSHARP is a novel component of the Notch/RBP-Jkappa signalling pathway.Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in DrosophilaSEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradationDirect inhibition of the NOTCH transcription factor complexThe Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretaseIdentification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1A novel mechanism for the regulation of amyloid precursor protein metabolismHydrogen bond dynamics in membrane protein functionInsights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's diseaseHydrogen peroxide sensing, signaling and regulation of transcription factorsForce-induced unfolding simulations of the human Notch1 negative regulatory region: possible roles of the heterodimerization domain in mechanosensingStructure and stability of the ankyrin domain of the Drosophila Notch receptorStructure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALLEffects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexesThree-dimensional structure of human γ-secretaseDelta-Notch signalling in segmentationProteomic Substrate Identification for Membrane Proteases in the BrainPAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragmentsPigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1Tumor necrosis factor-α regulates distinct molecular pathways and gene networks in cultured skeletal muscle cellsPresenilin promotes dietary copper uptakePresenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiencyMice lacking both presenilin genes exhibit early embryonic patterning defectsNotch-1 signaling regulates microglia activation via NF-κB pathway after hypoxic exposure in vivo and in vitroPresenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC)Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line.
P2860
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P2860
Presenilin is required for activity and nuclear access of Notch in Drosophila
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Presenilin is required for activity and nuclear access of Notch in Drosophila
@ast
Presenilin is required for activity and nuclear access of Notch in Drosophila
@en
Presenilin is required for activity and nuclear access of Notch in Drosophila
@nl
type
label
Presenilin is required for activity and nuclear access of Notch in Drosophila
@ast
Presenilin is required for activity and nuclear access of Notch in Drosophila
@en
Presenilin is required for activity and nuclear access of Notch in Drosophila
@nl
prefLabel
Presenilin is required for activity and nuclear access of Notch in Drosophila
@ast
Presenilin is required for activity and nuclear access of Notch in Drosophila
@en
Presenilin is required for activity and nuclear access of Notch in Drosophila
@nl
P3181
P356
P1433
P1476
Presenilin is required for activity and nuclear access of Notch in Drosophila
@en
P2093
P2888
P3181
P356
10.1038/19091
P407
P577
1999-04-08T00:00:00Z
P6179
1018973926