MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines
about
Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferasePTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complexKnockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.Structural Basis for WDR5 Interaction (Win) Motif Recognition in Human SET1 Family Histone MethyltransferasesTargeted Disruption of the Interaction Between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase ComplexesPancreatic Cancer, A Mis-interpreter of the Epigenetic LanguageCooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domainSMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cellsCpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signalsIn silico mining of EST databases for novel pre-implantation embryo-specific zinc finger protein genes.Maintenance of transposon-free regions throughout vertebrate evolutionEpigenetic regulator MLL2 shows altered expression in cancer cell lines and tumors from human breast and colon.Identification and characterization of the DNA binding domain of CpG-binding protein.Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation.Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.Genetic profile of acute myeloid leukemia.Challenges and opportunities in targeting the menin-MLL interaction.MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progressionHypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential.Identification of HBV-MLL4 Integration and Its Molecular Basis in Chinese Hepatocellular Carcinoma.Histone demethylases and cancer.A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.Epigenetic events in malignant melanoma.Cancer genetics of epigenetic genes.Histone H3 lysine 4 (H3K4) methylation in development and differentiationNuclear receptor coregulators in cancer biology.Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein.Glioma stem cell maintenance: the role of the microenvironment.Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.Integration of hepatitis B virus DNA into the myeloid/lymphoid or mixed-lineage leukemia (MLL4) gene and rearrangements of MLL4 in human hepatocellular carcinoma.De novo erythroleukemia chromosome features include multiple rearrangements, with special involvement of chromosomes 11 and 19.Frequent gain of chromosome 19 in megakaryoblastic leukemias detected by comparative genomic hybridization.Identification of an MLL4-GPS2 fusion as an oncogenic driver of undifferentiated spindle cell sarcoma in a child.Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction.Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2.Landscape of somatic mutations in gastric cancer assessed using next-generation sequencing analysis
P2860
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P2860
MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
MLL2, the second human homolog ...... fied in solid tumor cell lines
@ast
MLL2, the second human homolog ...... fied in solid tumor cell lines
@en
MLL2, the second human homolog ...... fied in solid tumor cell lines
@nl
type
label
MLL2, the second human homolog ...... fied in solid tumor cell lines
@ast
MLL2, the second human homolog ...... fied in solid tumor cell lines
@en
MLL2, the second human homolog ...... fied in solid tumor cell lines
@nl
prefLabel
MLL2, the second human homolog ...... fied in solid tumor cell lines
@ast
MLL2, the second human homolog ...... fied in solid tumor cell lines
@en
MLL2, the second human homolog ...... fied in solid tumor cell lines
@nl
P2093
P2860
P356
P1433
P1476
MLL2, the second human homolog ...... fied in solid tumor cell lines
@en
P2093
D G Huntsman
L M Wiedemann
S Aparicio
S J Batley
V P Collins
P2860
P2888
P304
P356
10.1038/SJ.ONC.1203291
P407
P577
1999-12-23T00:00:00Z
P5875
P6179
1020450775