Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2.
about
The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesisA double take on bivalent promotersHijacked in cancer: the KMT2 (MLL) family of methyltransferasesStructure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domainThe super elongation complex (SEC) and MLL in development and disease.Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesisDevelopmentally induced Mll1 loss reveals defects in postnatal haematopoiesisPAFc, a key player in MLL-rearranged leukemogenesis.The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Selective targeting of histone methylationDiscovery of MLL1 binding units, their localization to CpG Islands, and their potential function in mitotic chromatin.The pathogenesis of mixed-lineage leukemia.Acute dietary zinc deficiency before conception compromises oocyte epigenetic programming and disrupts embryonic development.ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection.p27kip1 maintains a subset of leukemia stem cells in the quiescent state in murine MLL-leukemia.The molecular biology of mixed lineage leukemia.Molecular pathology of mixed-lineage leukemia.MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters.Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.Chromatin remodeling and bivalent histone modifications in embryonic stem cells.Paradoxical Effects of MLL Paralogs in MLL-Rearranged Leukemia.Distinct functions of histone H3, lysine 4 methyltransferases in normal and malignant hematopoiesis.SET/MLL family proteins in hematopoiesis and leukemia.Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells.Cytosine modifications modulate the chromatin architecture of transcriptional enhancers.Is H3K4me3 instructive for transcription activation?
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P2860
Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
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name
Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2.
@en
Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2.
@nl
type
label
Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2.
@en
Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2.
@nl
prefLabel
Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2.
@en
Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2.
@nl
P2093
P2860
P356
P1433
P1476
Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2
@en
P2093
M P Garcia-Cuellar
P2860
P2888
P304
P356
10.1038/ONC.2008.443
P407
P577
2008-12-08T00:00:00Z