CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1
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Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygenSiglecs as sensors of self in innate and adaptive immune responsesSiglecs and immune regulationSialic acid binding domains of CD22 are required for negative regulation of B cell receptor signalingTargeting CD22 with the monoclonal antibody epratuzumab modulates human B-cell maturation and cytokine production in response to Toll-like receptor 7 (TLR7) and B-cell receptor (BCR) signalingThe tyrosine 343 residue of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) is important for its interaction with SHP1, a cytoplasmic tyrosine phosphatase with tumor suppressor functions.A linkage map of transcribed single nucleotide polymorphisms in rohu (Labeo rohita) and QTL associated with resistance to Aeromonas hydrophila.The immunoglobulin tail tyrosine motif upgrades memory-type BCRs by incorporating a Grb2-Btk signalling module.ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signalingGrowth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction.B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse.Isotype control of B cell signaling.Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.Rapid T cell receptor-mediated SHP-1 S591 phosphorylation regulates SHP-1 cellular localization and phosphatase activityEnhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptorsAnti-CD19 and anti-CD22 monoclonal antibodies increase the effectiveness of chemotherapy in Pre-B acute lymphoblastic leukemia cell lines.Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling.Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells.Increased IL-12 inhibits B cells' differentiation to germinal center cells and promotes differentiation to short-lived plasmablasts.STALing B cell responses with CD22.Negative signaling by inhibitory receptors: the NK cell paradigm.CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling.Pivotal advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner.The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop.Emerging therapies for B-cell non-Hodgkin lymphoma.Besides an ITIM/SHP-1-dependent pathway, CD22 collaborates with Grb2 and plasma membrane calcium-ATPase in an ITIM/SHP-1-independent pathway of attenuation of Ca2+i signal in B cells.Targeting CD22 in B-cell malignancies: current status and clinical outlook.CD22 and Siglec-G regulate inhibition of B-cell signaling by sialic acid ligand binding and control B-cell tolerance.Molecular targets on B-cells to prevent and treat antibody-mediated rejection in organ transplantation. Present and Future.Viewing Siglecs through the lens of tumor immunology.CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk.SHP-1 inhibition by 4-hydroxynonenal activates Jun N-terminal kinase and glutamate cysteine ligase.CD22 is a recycling receptor that can shuttle cargo between the cell surface and endosomal compartments of B cells.Engagement of CD22 on B cells with the monoclonal antibody epratuzumab stimulates the phosphorylation of upstream inhibitory signals of the B cell receptor.PhenomeExpress: a refined network analysis of expression datasets by inclusion of known disease phenotypes.Novel binding site for Src homology 2-containing protein-tyrosine phosphatase-1 in CD22 activated by B lymphocyte stimulation with antigen.Cytotoxic activity of gemtuzumab ozogamicin (Mylotarg) in acute myeloid leukemia correlates with the expression of protein kinase Syk.A CD22-reactive TCR from the T-cell allorepertoire for the treatment of acute lymphoblastic leukemia by TCR gene transfer.Regulation of B cell functions by the sialic acid-binding receptors siglec-G and CD22.The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation.
P2860
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P2860
CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
CD22 regulates B cell receptor ...... ndently recruit Grb2 and SHP-1
@ast
CD22 regulates B cell receptor ...... ndently recruit Grb2 and SHP-1
@en
CD22 regulates B cell receptor ...... ndently recruit Grb2 and SHP-1
@nl
type
label
CD22 regulates B cell receptor ...... ndently recruit Grb2 and SHP-1
@ast
CD22 regulates B cell receptor ...... ndently recruit Grb2 and SHP-1
@en
CD22 regulates B cell receptor ...... ndently recruit Grb2 and SHP-1
@nl
prefLabel
CD22 regulates B cell receptor ...... ndently recruit Grb2 and SHP-1
@ast
CD22 regulates B cell receptor ...... ndently recruit Grb2 and SHP-1
@en
CD22 regulates B cell receptor ...... ndently recruit Grb2 and SHP-1
@nl
P2860
P921
P3181
P356
P1476
CD22 regulates B cell receptor ...... ndently recruit Grb2 and SHP-1
@en
P2093
P2860
P304
44315-44322
P3181
P356
10.1074/JBC.M105446200
P407
P577
2001-09-10T00:00:00Z