APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes
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The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complexHuman CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complexSyntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide productionAssociation of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegenerationTargeting γ-secretase in breast cancerToward the structure of presenilin/γ-secretase and presenilin homologsStructural biology of presenilin 1 complexesSUMO1 Affects Synaptic Function, Spine Density and MemoryThree-dimensional structure of human γ-secretaseAn atomic structure of human γ-secretaseA conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complexGamma-secretase complex assembly within the early secretory pathwayΓ-secretase components as predictors of breast cancer outcomeAph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substratesPresenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brainAn E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-proteinSpatial segregation of gamma-secretase and substrates in distinct membrane domains.Structural basis of human γ-secretase assembly.Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments.Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations.OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin.Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.microRNA Expression Profiling of Propofol-Treated Developing Rat Hippocampal AstrocytesPresenilin function and gamma-secretase activity.Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex.Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domainThe role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloidSubstrate specificity of gamma-secretase and other intramembrane proteases.Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease.Gamma-secretase inhibition and modulation for Alzheimer's disease.Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation.Prostaglandin I2 upregulates the expression of anterior pharynx-defective-1α and anterior pharynx-defective-1β in amyloid precursor protein/presenilin 1 transgenic mice.APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes
P2860
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P2860
APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
APH-1 interacts with mature an ...... presenilin.nicastrin complexes
@ast
APH-1 interacts with mature an ...... presenilin.nicastrin complexes
@en
APH-1 interacts with mature an ...... presenilin.nicastrin complexes
@nl
type
label
APH-1 interacts with mature an ...... presenilin.nicastrin complexes
@ast
APH-1 interacts with mature an ...... presenilin.nicastrin complexes
@en
APH-1 interacts with mature an ...... presenilin.nicastrin complexes
@nl
prefLabel
APH-1 interacts with mature an ...... presenilin.nicastrin complexes
@ast
APH-1 interacts with mature an ...... presenilin.nicastrin complexes
@en
APH-1 interacts with mature an ...... presenilin.nicastrin complexes
@nl
P2093
P50
P3181
P356
P1476
APH-1 interacts with mature an ...... presenilin.nicastrin complexes
@en
P2093
Anchla Luthra
Anurag Tandon
Fusheng Chen
Hiroshi Hasegawa
Howard T J Mount
Monica Duthie
Paul E Fraser
Wenping Li
Xueying Ruan
Yongjun Gu
P304
P3181
P356
10.1074/JBC.M209499200
P407
P577
2003-02-28T00:00:00Z