about
SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 productionKilling Me Softly: Connotations to Unfolded Protein Response and Oxidative Stress in Alzheimer's DiseasePresenilin function in Caenorhabditis elegansAssembly, trafficking and function of gamma-secretasePigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1Molecular profiling reveals diversity of stress signal transduction cascades in highly penetrant Alzheimer's disease human skin fibroblastsP60TRP interferes with the GPCR/secretase pathway to mediate neuronal survival and synaptogenesisAmyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation.Early life nutrient restriction impairs blood-brain metabolic profile and neurobehavior predisposing to Alzheimer's disease with aging.Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.Transgenic Drosophila models of Alzheimer's disease and tauopathiesCharacterization of an atypical gamma-secretase complex from hematopoietic originA presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activityγ-Secretase inhibition of murine choroidal neovascularization is associated with reduction of superoxide and proinflammatory cytokines.Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers.Neuregulin upregulates microglial α7 nicotinic acetylcholine receptor expression in immortalized cell lines: implications for regulating neuroinflammationNeuronal death in Alzheimer's disease and therapeutic opportunities.Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivoNext Generation Sequencing Identifies Five Major Classes of Potentially Therapeutic Enzymes Secreted by Lucilia sericata Medical MaggotsAn update of animal models of Alzheimer disease with a reevaluation of plaque depositions.Regulating amyloid precursor protein synthesis through an internal ribosomal entry site.Global topology analysis of pancreatic zymogen granule membrane proteins.Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretaseSubstrate specificity of gamma-secretase and other intramembrane proteases.gamma-Secretase: a multifaceted regulator of angiogenesisGenetics of Alzheimer's disease: recent advances.Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosisPossible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage.Dietary deficiency increases presenilin expression, gamma-secretase activity, and Abeta levels: potentiation by ApoE genotype and alleviation by S-adenosyl methionine.Regulated intramembrane proteolysis of the TGFβ type I receptor conveys oncogenic signals.TRAF6 stimulates the tumor-promoting effects of TGFβ type I receptor through polyubiquitination and activation of presenilin 1.Neurocognitive Effect of Nootropic Drug Brahmi (Bacopa monnieri) in Alzheimer's Disease.Notch signaling is necessary for epithelial growth arrest by TGF-beta.Presenilin 1 affects focal adhesion site formation and cell force generation via c-Src transcriptional and posttranslational regulation.Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis.Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and gamma-secretase-dependent E-cadherin cleavage.Molecular characterization and temporal expression profiling of presenilins in the developing porcine brain.Transcriptome analysis revealed impaired cAMP responsiveness in PHF21A-deficient human cells.Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader.Increased prevalence of significant recurrent headache in preclinical familial Alzheimer's disease mutation carriers.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Presenilin function and gamma-secretase activity.
@ast
Presenilin function and gamma-secretase activity.
@en
type
label
Presenilin function and gamma-secretase activity.
@ast
Presenilin function and gamma-secretase activity.
@en
prefLabel
Presenilin function and gamma-secretase activity.
@ast
Presenilin function and gamma-secretase activity.
@en
P2860
P1476
Presenilin function and gamma-secretase activity.
@en
P2093
P2860
P304
P356
10.1111/J.1471-4159.2005.03099.X
P407
P577
2005-05-01T00:00:00Z