Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
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Global microRNA characterization reveals that miR-103 is involved in IGF-1 stimulated mouse intestinal cell proliferationWhat does the concept of the stem cell niche really mean today?R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell linesTumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptorsNuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formationConstitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi networkWnt/β-catenin signaling regulates telomerase in stem cells and cancer cellsLGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signalingHomeostasis and inflammation in the intestineInterleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host diseaseHeparin-binding EGF-like growth factor protects intestinal stem cells from injury in a rat model of necrotizing enterocolitis.Basic helix-loop-helix transcription factors and enteroendocrine cell differentiationMature chief cells are cryptic progenitors for metaplasia in the stomachMammary Development and Breast Cancer: A Wnt PerspectivehPSC-derived lung and intestinal organoids as models of human fetal tissuePaneth cell α-defensins and enteric microbiota in health and diseaseControl of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in CancerStem Cells in the Intestine: Possible Roles in Pathogenesis of Irritable Bowel SyndromeIntegration of Signaling Pathways with the Epigenetic Machinery in the Maintenance of Stem CellsThe role of enterocyte defects in the pathogenesis of congenital diarrheal disordersOrganoid Models of Human Gastrointestinal Development and DiseaseLingual Epithelial Stem Cells and Organoid Culture of ThemPrecision medicine for cancer with next-generation functional diagnosticsModeling psychiatric disorders for developing effective treatmentsLGR4 and Its Role in Intestinal Protection and Energy MetabolismMouse models of intestinal cancerSimilar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistanceColorectal cancer models for novel drug discoveryThe many ways to make a luminal cell and a prostate cancer cellThe mammary stem cell hierarchy: a looking glass into heterogeneous breast cancer landscapesCancer Cell Line Panels Empower Genomics-Based Discovery of Precision Cancer MedicineUnderstanding the complexities of Salmonella-host crosstalk as revealed by in vivo model organismsInnate lymphoid cells in graft-versus-host diseaseThe potential of mesenchymal stem cells in the management of radiation enteropathyReserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tractWound repair: role of immune-epithelial interactionsWhole-organ re-engineering: a regenerative medicine approach to digestive organ replacementTissue communication in regenerative inflammatory signaling: lessons from the fly gutAdult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins
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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
description
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 2009
@ast
scientific article (publication date: 14 May 2009)
@en
vedecký článok (publikovaný 2009/05/14)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/05/14)
@nl
наукова стаття, опублікована в травні 2009
@uk
مقالة علمية (نشرت في 14-5-2009)
@ar
name
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
@ast
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
@en
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
@nl
type
label
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
@ast
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
@en
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
@nl
prefLabel
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
@ast
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
@en
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
@nl
P2093
P3181
P356
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P1476
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
@en
P2093
Hans Clevers
Hugo J Snippert
Johan H van Es
Marc van de Wetering
Nick Barker
Pekka Kujala
Peter J Peters
Robert G Vries
Toshiro Sato
P2888
P3181
P356
10.1038/NATURE07935
P407
P577
2009-05-14T00:00:00Z
P5875
P6179
1024082069