Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
about
Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cellsInteraction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signalingGrowth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 proteinInterleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor geneIdentification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II.Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral stateDifferent interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferationA novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptorsTec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor bindingDirect association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiationRegulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesityHierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activationCharacterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activationThe conserved box 1 motif of cytokine receptors is required for association with JAK kinasesExpression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cellsRegions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptorInterleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinasesA kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cellsInterleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytesPhosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptorMucin biosynthesis: upregulation of core 2 beta 1,6 N-acetylglucosaminyltransferase by retinoic acid and Th2 cytokines in a human airway epithelial cell linep70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytesConsequences of Stat6 deletion on Sis/PDGF- and IL-4-induced proliferation and transcriptional activation in murine fibroblastsDistinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversityMolecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transductionJanus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferonsTyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signalingPyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathwayPlatelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteinsInterferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinaseGenetic variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes are prognostic markers of prostate cancer-specific mortality.Tumor-shed PGE(2) impairs IL2Rgammac-signaling to inhibit CD4 T cell survival: regulation by theaflavins.The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexesProtein phosphatase 2A regulates interleukin-2 receptor complex formation and JAK3/STAT5 activation.
P2860
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P2860
Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
description
1994 nî lūn-bûn
@nan
1994 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Involvement of the Jak-3 Janus ...... in lymphoid and myeloid cells
@ast
Involvement of the Jak-3 Janus ...... in lymphoid and myeloid cells
@en
Involvement of the Jak-3 Janus ...... in lymphoid and myeloid cells
@nl
type
label
Involvement of the Jak-3 Janus ...... in lymphoid and myeloid cells
@ast
Involvement of the Jak-3 Janus ...... in lymphoid and myeloid cells
@en
Involvement of the Jak-3 Janus ...... in lymphoid and myeloid cells
@nl
prefLabel
Involvement of the Jak-3 Janus ...... in lymphoid and myeloid cells
@ast
Involvement of the Jak-3 Janus ...... in lymphoid and myeloid cells
@en
Involvement of the Jak-3 Janus ...... in lymphoid and myeloid cells
@nl
P2093
P921
P3181
P356
P1433
P1476
Involvement of the Jak-3 Janus ...... in lymphoid and myeloid cells
@en
P2093
B A Witthuhn
O Silvennoinen
P2888
P3181
P356
10.1038/370153A0
P407
P577
1994-07-14T00:00:00Z
P6179
1036067090