APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy
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Current Insights into Molecular Mechanisms of Alzheimer Disease and Their Implications for Therapeutic ApproachesProspects for Improving Brain Function in Individuals with Down SyndromeAnalysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individualsRelationships between expression of apolipoprotein E and beta-amyloid precursor protein are altered in proximity to Alzheimer beta-amyloid plaques: potential explanations from cell culture studiesDysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosisIntracerebral haemorrhage in Down syndrome: protected or predisposed?Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal CompoundsDissecting Alzheimer disease in Down syndrome using mouse modelsMisframed ubiquitin and impaired protein quality control: an early event in Alzheimer's diseaseThe genetic landscape of Alzheimer disease: clinical implications and perspectivesA genetic cause of Alzheimer disease: mechanistic insights from Down syndromeAutosomal Dominant Alzheimer Disease: A Unique Resource to Study CSF Biomarker Changes in Preclinical ADCaenorhabditis elegans as a model organism to study APP functionThe genetics and neuropathology of Alzheimer's diseaseInconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's diseaseNebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signalingThree dimensions of the amyloid hypothesis: time, space and 'wingmen'Genetic diagnosis and prognosis of Alzheimer's disease: challenges and opportunitiesAdditional mechanisms conferring genetic susceptibility to Alzheimer's diseaseReduced purifying selection prevails over positive selection in human copy number variant evolutionThe amyloid-beta precursor protein is phosphorylated via distinct pathways during differentiation, mitosis, stress, and degeneration.Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides.Allele-specific RNAi mitigates phenotypic progression in a transgenic model of Alzheimer's disease.Copy number variants and common disorders: filling the gaps and exploring complexity in genome-wide association studies.Multiplex Amplicon Quantification (MAQ), a fast and efficient method for the simultaneous detection of copy number alterations in neuroblastomaAlzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP.Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.Excess betaCTF, not Abeta: the culprit in Alzheimer-related endocytic dysfunction.Clinical genetics of Alzheimer's diseaseRecent insights into the molecular genetics of dementiaGenetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.Current status on Alzheimer disease molecular genetics: from past, to present, to future.Understanding microRNAs in neurodegeneration.Copy number variation in human health, disease, and evolution.Genetic spectrum of hereditary neuropathies with onset in the first year of lifeGenetics of psychosis in Alzheimer's disease: a reviewThe genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE.Probing the biology of Alzheimer's disease in mice.An Intron 7 Polymorphism in APP Affects the Age of Onset of Dementia in Down Syndrome.Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model.
P2860
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P2860
APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy
description
2006 nî lūn-bûn
@nan
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
APP duplication is sufficient ...... th cerebral amyloid angiopathy
@ast
APP duplication is sufficient ...... th cerebral amyloid angiopathy
@en
APP duplication is sufficient ...... th cerebral amyloid angiopathy
@nl
type
label
APP duplication is sufficient ...... th cerebral amyloid angiopathy
@ast
APP duplication is sufficient ...... th cerebral amyloid angiopathy
@en
APP duplication is sufficient ...... th cerebral amyloid angiopathy
@nl
prefLabel
APP duplication is sufficient ...... th cerebral amyloid angiopathy
@ast
APP duplication is sufficient ...... th cerebral amyloid angiopathy
@en
APP duplication is sufficient ...... th cerebral amyloid angiopathy
@nl
P2093
P50
P3181
P356
P1433
P1476
APP duplication is sufficient ...... th cerebral amyloid angiopathy
@en
P2093
Jan Wauters
Jurgen Del-Favero
Marc Cruts
P304
P3181
P356
10.1093/BRAIN/AWL203
P407
P50
P577
2006-11-01T00:00:00Z