Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.
about
Dissecting Alzheimer disease in Down syndrome using mouse modelsThe endosomal-lysosomal system: from acidification and cargo sorting to neurodegenerationA genetic cause of Alzheimer disease: mechanistic insights from Down syndromeCellular mechanisms of γ-secretase substrate selection, processing and toxicityA γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APPAmyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegenerationRab GTPases, membrane trafficking and diseasesTrisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomesAxonal transport and neurodegenerative disease: can we see the elephant?Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cellsLoss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbancesModifications of the endosomal compartment in peripheral blood mononuclear cells and fibroblasts from Alzheimer's disease patientsLigand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway.The burden of trisomy 21 disrupts the proteostasis network in Down syndrome.Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein.Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression.Excess betaCTF, not Abeta: the culprit in Alzheimer-related endocytic dysfunction.Pharmacological chaperones stabilize retromer to limit APP processing.Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's diseaseThe acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice.Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction.Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion.Age and gene overexpression interact to abolish nesting behavior in Tg2576 amyloid precursor protein (APP) miceReversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficitsExpression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice.Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's diseaseModulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model.An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach.Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD).Autophagy failure in Alzheimer's disease--locating the primary defect.A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway.Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease.Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generationDifferential regulation of catechol-O-methyltransferase expression in a mouse model of aggression.Nanoparticle-mediated signaling endosome localization regulates growth cone motility and neurite growth.Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic miceNeuroinflammatory Cytokines-The Common Thread in Alzheimer's PathogenesisAge-related neurodegeneration and memory loss in down syndrome.BACE2 expression increases in human neurodegenerative disease.Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy.
P2860
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P2860
Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Alzheimer's-related endosome d ...... reversed by BACE-1 inhibition.
@ast
Alzheimer's-related endosome d ...... reversed by BACE-1 inhibition.
@en
type
label
Alzheimer's-related endosome d ...... reversed by BACE-1 inhibition.
@ast
Alzheimer's-related endosome d ...... reversed by BACE-1 inhibition.
@en
prefLabel
Alzheimer's-related endosome d ...... reversed by BACE-1 inhibition.
@ast
Alzheimer's-related endosome d ...... reversed by BACE-1 inhibition.
@en
P2093
P2860
P356
P1476
Alzheimer's-related endosome d ...... reversed by BACE-1 inhibition
@en
P2093
Anne Boyer-Boiteau
Anne M Cataldo
Corrinne M Peterhoff
Kerry A Mullaney
Ralph A Nixon
Shaoli Che
Stephen D Schmidt
Ying Jiang
P2860
P304
P356
10.1073/PNAS.0908953107
P407
P577
2009-12-28T00:00:00Z